{
  "abstract": "BACKGROUND Contrast-associated acute kidney injury (CA-AKI) is a recognized complication in oncology patients undergoing contrast-enhanced computed tomography (CECT) during chemotherapy. Limited data exist on CA-AKI incidence in patients with preserved baseline renal function, particularly in Middle Eastern populations. MATERIAL AND METHODS We conducted a retrospective analysis of 146 adult oncology patients with baseline estimated glomerular filtration rate (eGFR) greater than 50 mL/min/1.73 m² who underwent CECT within 45 days of chemotherapy at a tertiary cancer center in Saudi Arabia (January 2017-December 2018). CA-AKI was defined as an absolute serum creatinine increase of 0.3 mg/dL or more, or as a relative increase of more than 50% within 48 to 72 hours of contrast administration. Given the small number of events (n=2), descriptive statistics and exploratory univariate analyses were performed. RESULTS CA-AKI occurred in 2 of 146 patients (1.4%; 95% CI: 0.2%-5.0%). Mean age was 51.5±16.2 years; 58% were women. Cancer types included solid tumors (81.5%) and hematological malignancies (17.8%). The chemotherapy-to-CECT interval was shorter in patients with CA-AKI (mean: 2 days) than in patients without CA-AKI (mean: 23.3±12.8 days; P=0.02). This association is exploratory and hypothesis-generating given the extremely limited number of events. CONCLUSIONS CA-AKI incidence was relatively low (1.4%) in oncology patients with preserved baseline renal function undergoing CECT during active chemotherapy. The observed association between shorter chemotherapy-to-imaging intervals and CA-AKI requires prospective validation and should not be interpreted as a definitive causal relationship. These findings provide preliminary regional data from Saudi Arabia and underscore the need for larger, well-designed prospective studies to better characterize CA-AKI risk in this population.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiology, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia.",
    "Department of Internal Medicine, King Abdulaziz Medical City, Ministry of National Guard, Jeddah, Saudi Arabia.",
    "Department of Radiology, King Faisal Specialist Hospital and Research Centre, Madinah, Saudi Arabia."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Abdulmalek Alzahrani"
    },
    {
      "affs": [
        0
      ],
      "name": "Mohammad Alsayed",
      "orcid": "0009-0003-0543-2056"
    },
    {
      "affs": [
        0
      ],
      "name": "Salah Shihata",
      "orcid": "0000-0002-9848-1345"
    },
    {
      "affs": [
        0
      ],
      "name": "Wgoud Mohamed"
    },
    {
      "affs": [
        1
      ],
      "name": "Mohammed S Alqarni"
    },
    {
      "affs": [
        0
      ],
      "name": "Rahaf Almoallim",
      "orcid": "0000-0002-4250-6865"
    },
    {
      "affs": [
        0
      ],
      "name": "Abdulaziz Khiyami"
    },
    {
      "affs": [
        2
      ],
      "name": "Abdullah Felemban",
      "orcid": "0000-0003-1766-085X"
    },
    {
      "affs": [
        0
      ],
      "name": "Majed Ashour"
    },
    {
      "affs": [
        0
      ],
      "name": "Zergham Zia"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/44dn0tdjz0t33.bib",
  "cited_by": 0,
  "doi": "10.12659/msm.953198",
  "fulltext_url": "https://europepmc.org/articles/PMC13700542",
  "id": "44dn0tdjz0t33",
  "issns": [
    "1234-1010",
    "1643-3750"
  ],
  "landing_url": "https://europepmc.org/article/MED/42902549",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2727|Acute Kidney Injury Research"
    ]
  ],
  "openalex": "W7203738661",
  "pdf_url": "https://europepmc.org/articles/PMC13700542?pdf=render",
  "pmcid": "PMC13700542",
  "pmid": "42902549",
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/44dn0tdjz0t33.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42902549",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42902549"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Acute Kidney Injury Research",
      "subfield": "general"
    }
  ],
  "title": "Contrast-Associated Acute Kidney Injury in Oncology Patients During Active Chemotherapy: A Saudi Arabian Retrospective Study.",
  "title_text": "Contrast-Associated Acute Kidney Injury in Oncology Patients During Active Chemotherapy: A Saudi Arabian Retrospective Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:32Z",
  "url": "https://research.draconitic.com/paper/44dn0tdjz0t33",
  "venue": "Medical science monitor : international medical journal of experimental and clinical research",
  "versions": []
}