{
  "abstract": "Tuberculosis (TB) remains the leading infectious cause of death worldwide, with India accounting for nearly one-fourth of global TB cases. Ni-kshay, the country’s digital case-based TB notification platform is rich in data pertaining to the continuum of care of TB patients. This study aims to develop a standardized analytical approach to programmatic data to identify predictors of unfavourable treatment outcomes and mortality among adult drug-sensitive TB patients at the state level for Maharashtra during 2021 and 2022. Two separate analyses were undertaken comparing treatment success with: (1) unfavourable outcomes (death, treatment failure, loss to follow-up, regimen change, or not evaluated); and (2) mortality. Age group, gender and pre-treatment weight were entered together in a single logistic regression model, and each remaining risk factor was entered into a separate model alongside those three covariates, to compute adjusted odds ratios (aOR). Records with no entry for diabetes, HIV, tobacco or alcohol were retained as a “not recorded” or “unknown” category. Collinearity across variables was assessed using Cramer’s V and variance inflation factors. The final cohort included 323,124 cases for unfavourable outcome analysis and 315,579 cases for mortality analysis. Increasing age, male gender, lower body weight, known HIV and diabetes comorbidities, tobacco and alcohol consumption, and “unknown” status for behavioural risks and comorbidity status were significantly associated with increased odds of both unfavourable outcomes and mortality. This study highlights the utility of programmatic data in identifying high-risk TB patients and offers a reproducible analytic framework.",
  "abstract_shown": true,
  "affiliations": [
    "National Disease Modelling Consortium, Indian Institute of Technology, Mumbai, India",
    "Department of Physics, Indian Institute of Technology, Mumbai, India",
    "Department of Chemical Engineering, Indian Institute of Technology, Mumbai, India",
    "Central Tuberculosis (TB) Division, National TB Elimination Programme, Ministry of Health and Family Welfare, Government of India, New Delhi, India"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Raghavan Parthasarathy"
    },
    {
      "affs": [
        1
      ],
      "name": "Yashi Raj"
    },
    {
      "affs": [
        2
      ],
      "name": "Nabanita Majumder"
    },
    {
      "affs": [
        3
      ],
      "name": "Mithun Mitra"
    },
    {
      "name": "Sarika Mehra"
    },
    {
      "name": "Raghuram Rao"
    },
    {
      "name": "Shobini Rajan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/44fm0mzj04z73.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pgph.0006539",
  "fulltext_url": "https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0006539",
  "id": "44fm0mzj04z73",
  "issns": [
    "2767-3375"
  ],
  "landing_url": "https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0006539",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "plos",
      "/Biology and life sciences/Microbiology/Medical microbiology/Microbial pathogens/Viral pathogens/Immunodeficiency viruses/HIV"
    ],
    [
      "plos",
      "/Biology and life sciences/Microbiology/Medical microbiology/Microbial pathogens/Viral pathogens/Retroviruses/Lentivirus/HIV"
    ],
    [
      "plos",
      "/Biology and life sciences/Nutrition/Diet/Alcohol consumption"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Viruses/Immunodeficiency viruses/HIV"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Viruses/RNA viruses/Retroviruses/Lentivirus/HIV"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Viruses/Viral pathogens/Immunodeficiency viruses/HIV"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Viruses/Viral pathogens/Retroviruses/Lentivirus/HIV"
    ],
    [
      "plos",
      "/Biology and life sciences/Physiology/Physiological parameters/Body weight"
    ],
    [
      "plos",
      "/Medicine and health sciences/Endocrinology/Endocrine disorders/Diabetes mellitus"
    ],
    [
      "plos",
      "/Medicine and health sciences/Epidemiology/Medical risk factors"
    ],
    [
      "plos",
      "/Medicine and health sciences/Medical conditions/Infectious diseases/Bacterial diseases/Tuberculosis"
    ],
    [
      "plos",
      "/Medicine and health sciences/Medical conditions/Metabolic disorders/Diabetes mellitus"
    ],
    [
      "plos",
      "/Medicine and health sciences/Medical conditions/Tropical diseases/Tuberculosis"
    ],
    [
      "plos",
      "/Medicine and health sciences/Nutrition/Diet/Alcohol consumption"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pathology and laboratory medicine/Pathogens/Microbial pathogens/Viral pathogens/Immunodeficiency viruses/HIV"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pathology and laboratory medicine/Pathogens/Microbial pathogens/Viral pathogens/Retroviruses/Lentivirus/HIV"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pharmaceutics/Drug therapy"
    ],
    [
      "plos",
      "/People and places/Geographical locations/Asia/India"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0006539&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/44fm0mzj04z73.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:20:24Z",
      "native_id": "10.1371/journal.pgph.0006539",
      "source": "plos",
      "url": "https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0006539"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "plos:microbiology",
      "subfield": "microbiology"
    },
    {
      "field": "medicine",
      "origin": "plos:endocrinology",
      "subfield": "endocrinology-metabolism"
    },
    {
      "field": "medicine",
      "origin": "plos:nutrition",
      "subfield": "nutrition"
    }
  ],
  "title": "Predictors of treatment outcomes in adults with drug–sensitive Tuberculosis in Maharashtra, India: A retrospective study",
  "title_text": "Predictors of treatment outcomes in adults with drug–sensitive Tuberculosis in Maharashtra, India: A retrospective study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:20:48Z",
  "url": "https://research.draconitic.com/paper/44fm0mzj04z73",
  "venue": "PLOS Global Public Health",
  "versions": []
}