{
  "abstract": "Ankyrin-B (AnkB), encoded by ANK2, is essential for ion channel localization in the heart. We investigated its role in regulating sinoatrial node (SAN) responses to autonomic input. AnkB-haploinsufficient (AnkB+/-) mice showed baseline bradycardia, heightened SAN response to β-adrenergic stimulation, and increased heart rate variability. These mice exhibited reduced ICa,L and SAN sarcoplasmic reticulum Ca2+ content, unchanged IK,ACh density, but impaired IK,ACh desensitization. AnkB interacts with GIRK1/4 subunits, and its loss in cardiomyocyte-specific knockout mice reduced GIRK1 membrane localization. Our findings support that AnkB deficiency disrupts autonomic regulation of SAN function through downregulation of ICa,L and the reduction in IK,ACh desensitization.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "name": "Jingdong Li"
    },
    {
      "name": "Crystal F Kline"
    },
    {
      "name": "Omer Cavus"
    },
    {
      "name": "John T Bobik"
    },
    {
      "name": "Nipun Malhotra"
    },
    {
      "name": "Jagun Raghavan"
    },
    {
      "name": "Sarah S Takenaka"
    },
    {
      "name": "Junie Kwak"
    },
    {
      "name": "Ryan J Cordeiro"
    },
    {
      "name": "Eleanor J Mohler"
    },
    {
      "name": "Emma Dudley"
    },
    {
      "name": "Xianyao Xu"
    },
    {
      "name": "Drew M Nassal"
    },
    {
      "name": "Yuejin Wu"
    },
    {
      "name": "Thomas J Hund"
    },
    {
      "name": "Matteo E Mangoni"
    },
    {
      "name": "Peter J Mohler"
    },
    {
      "name": "Mona El Refaey"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/44rfaf34xf83d.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jacbts.2026.101647",
  "fulltext_url": null,
  "id": "44rfaf34xf83d",
  "issns": [
    "2452-302X"
  ],
  "landing_url": "https://hal.science/hal-05850209v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.bc"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "hal",
      "2.sdv.mhep.csc"
    ],
    [
      "openalex",
      "2705|Cardiac electrophysiology and arrhythmias"
    ]
  ],
  "openalex": "W7202161991",
  "pdf_url": "https://hal.science/hal-05850209/document",
  "pmcid": null,
  "pmid": "42580048",
  "published": "2026-11-03",
  "publisher": "Elsevier on behalf of the American College of Cardiology Foundation",
  "ris": "https://research.draconitic.com/paper/44rfaf34xf83d.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:20:52Z",
      "native_id": "hal-05850209",
      "source": "hal",
      "url": "https://hal.science/hal-05850209v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.bc",
      "subfield": "cell-biology"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.mhep.csc",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Dysfunction in Ankyrin-B Disrupts Heart Rate Regulation by Altering the Membrane Abundance of GIRK Channels",
  "title_text": "Dysfunction in Ankyrin-B Disrupts Heart Rate Regulation by Altering the Membrane Abundance of GIRK Channels",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:20:52Z",
  "url": "https://research.draconitic.com/paper/44rfaf34xf83d",
  "venue": "JACC : Basic to Translational Science",
  "versions": []
}