{
  "abstract": "Background\n\nSinonasal malignancies are rare and histologically diverse, with limited population-based data from Asia. This study investigated the histologic distribution, factors associated with overall survival (OS), and temporal survival patterns in Taiwan.Methods\n\nThis retrospective population-based study used linked data from the Taiwan National Health Insurance Research Database and Taiwan Cancer Registry. Adults with invasive nasal cavity or paranasal sinus malignancies diagnosed between 2009 and 2019 were included. Factors associated with OS were evaluated using multivariable Cox regression analysis separately for hematological and nonhematological malignancies.Results\n\nAmong 1494 patients, 718 (48.1%) had hematological malignancies, and 776 (51.9%) had nonhematological malignancies. Squamous cell carcinoma predominated among nonhematological malignancies, whereas T-cell and NK/T-cell lymphomas were more common than mature B-cell lymphomas among hematological malignancies. Increasing age was associated with a higher hazard of death in both groups. In nonhematological malignancies, recorded surgical procedures were associated with a lower hazard of death (adjusted hazard ratio [aHR], 0.52; 95% CI, 0.42-0.66), whereas chemotherapy was associated with a higher hazard (aHR, 1.81; 95% CI, 1.36-2.39). In hematological malignancies, diagnosis during 2015-2019 was associated with a lower hazard of death than during 2009-2014 (aHR, 0.76; 95% CI, 0.60-0.96).Conclusion\n\nSinonasal malignancies in Taiwan showed distinct histologic and survival patterns. The predominance of T-cell and NK/T-cell neoplasms and improved survival in the more recent period highlight important epidemiological characteristics of hematological sinonasal malignancies in Taiwan.Level of evidence\n\n3.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medical Education Taichung Veterans General Hospital Taichung Taiwan.",
    "Department of Public Health College of Medicine, Fu Jen Catholic University New Taipei City Taiwan.",
    "Department of Industrial Engineering and Enterprise Information Tunghai University Taichung Taiwan.",
    "Institute of Public Health and Community Medicine Research Center National Yang Ming Chiao Tung University Taipei Taiwan.",
    "Department of Otolaryngology Taichung Veterans General Hospital Taichung Taiwan.",
    "School of Medicine, National Yang Ming Chiao Tung University Taipei Taiwan.",
    "School of Medicine, Chung Shan Medical University Taichung Taiwan.",
    "Department of Post-Baccalaureate Medicine College of Medicine, National Chung Hsing University Taichung Taiwan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Chi-Hsien Wu",
      "orcid": "0009-0001-8624-1360"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Ching-Heng Lin"
    },
    {
      "affs": [
        4,
        5,
        6,
        7
      ],
      "name": "Kai-Li Liang",
      "orcid": "0000-0002-2530-6685"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/44x6k1s1zct03.bib",
  "cited_by": 0,
  "doi": "10.1002/lio2.70613",
  "fulltext_url": "https://europepmc.org/articles/PMC13686811",
  "id": "44x6k1s1zct03",
  "issns": [
    "2378-8038"
  ],
  "landing_url": "https://europepmc.org/article/MED/42923043",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Head and Neck Surgical Oncology"
    ]
  ],
  "openalex": "W7223142889",
  "pdf_url": "https://europepmc.org/articles/PMC13686811?pdf=render",
  "pmcid": "PMC13686811",
  "pmid": "42923043",
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/44x6k1s1zct03.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42923043",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42923043"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Head and Neck Surgical Oncology",
      "subfield": "surgery"
    }
  ],
  "title": "Sinonasal Malignancies in Taiwan (2009-2019): Histologic Distribution, Overall Survival, and Temporal Trends in Hematological Versus Nonhematological Tumors.",
  "title_text": "Sinonasal Malignancies in Taiwan (2009-2019): Histologic Distribution, Overall Survival, and Temporal Trends in Hematological Versus Nonhematological Tumors.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:33Z",
  "url": "https://research.draconitic.com/paper/44x6k1s1zct03",
  "venue": "Laryngoscope investigative otolaryngology",
  "versions": []
}