{
  "abstract": "As a polyphenolic compound naturally found in nature, piceatannol is an analogue of resveratrol. These compounds share a common structural motif but have various substituents. Resveratrol shows anti-inflammation and anti-tumor properties, but such biological activities of the active resveratrol metabolite - piceatannol are unclear. In this study, the anti-tumor properties of piceatannol were investigated through cell viability, colony formation, migration assay, detection of reactive oxygen species (ROS) and mitochondrial membrane potential (MMP) change, reverse transcription quantitative polymerase chain reaction (RT-qPCR), and Western blotting in human hepatocellular carcinoma cell lines. Piceatannol decreased cell viability in a dose-dependent manner. These concentrations required to inhibit 50% of activity (IC₅₀) for Huh7, HepG2, and Hep3B cells were 76.1-99.7, 17.0-19.6, and 57.0-83.7 μM after 24-72 hour treatment, respectively. Piceatannol inhibited the abilities of colony-forming and migration of HCC cells. Piceatannol may contribute to cell death in hepatocellular carcinoma cells, accompanied by altered MMP, reduced expression of HSPD1 and increased DNA double strand breaks. Our results show that piceatannol, the metabolite of resveratrol, supports an anti-cancerogenic effect by inhibiting proliferation and promoting cell death. Moreover, piceatannol may be a more potent anticancer agent than resveratrol. Hence, piceatannol could be a candidate for anti-cancer compound for the management of liver cancer.",
  "abstract_shown": true,
  "affiliations": [
    "Division of General and Digestive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.",
    "Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.",
    "Center of Teaching and Research, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 812, Taiwan.",
    "Graduate Institute of Animal Vaccine Technology, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 912, Taiwan.",
    "Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.",
    "Center for Tropical Medicine and Infectious Disease Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan.",
    "Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.",
    "School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.",
    "Division of Hepatobiliary and Pancreatic Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.",
    "Department of Neurosurgery, E-Da Hospital, Kaohsiung 824, Taiwan.",
    "Mass Spectrometry Laboratory, Department of Chemistry, National University of Singapore, Singapore 119077, Singapore."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ming-Hui Yang"
    },
    {
      "affs": [
        1,
        2,
        3,
        4,
        5
      ],
      "name": "Yu-Chang Tyan"
    },
    {
      "affs": [
        0,
        6
      ],
      "name": "Hsin-Rou Liang"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Chia-Yen Dai"
    },
    {
      "affs": [
        9
      ],
      "name": "Yung-Jen Chuang"
    },
    {
      "affs": [
        10
      ],
      "name": "Cheng-Hui Yuan"
    },
    {
      "affs": [
        0,
        7
      ],
      "name": "Shih-Chang Chuang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/45v7q8yp2cnqf.bib",
  "cited_by": 0,
  "doi": "10.7150/ijms.127785",
  "fulltext_url": "https://europepmc.org/articles/PMC13685437",
  "id": "45v7q8yp2cnqf",
  "issns": [
    "1449-1907"
  ],
  "landing_url": "https://europepmc.org/article/MED/42910117",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Bioactive natural compounds"
    ]
  ],
  "openalex": "W7222904834",
  "pdf_url": "https://europepmc.org/articles/PMC13685437?pdf=render",
  "pmcid": "PMC13685437",
  "pmid": "42910117",
  "published": "2026-10-02",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/45v7q8yp2cnqf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42910117",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42910117"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Bioactive natural compounds",
      "subfield": "molecular-biology"
    }
  ],
  "title": "A naturally occurring polyphenolic compound for liver cancer treatment.",
  "title_text": "A naturally occurring polyphenolic compound for liver cancer treatment.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/45v7q8yp2cnqf",
  "venue": "International journal of medical sciences",
  "versions": []
}