{
  "abstract": "Background\n\nThis guideline was developed in collaboration with the Australasian Society of Clinical Immunology and Allergy (ASCIA), the National Allergy Council and the National Allergy Centre of Excellence (NACE). Despite the abundance of published penicillin allergy guidelines, few have been developed using rigorous evidence-based approaches such as the AGREE II framework.Objective\n\nThis guideline aims to provide recommendations for the assessment and management of adults with a penicillin allergy label, for Australian health professionals working in both community and specialist settings.Methods\n\nThe guideline was developed using the standardized, evidence-based AGREE II framework, consumer input, and a Delphi-based consensus process, involving a multidisciplinary panel of 27 drug allergy experts. Recommendations were informed by a rapid overview of reviews and existing guidelines.Results\n\nA total of 37 recommendations reached consensus, covering risk stratification, testing protocols, challenge test outcomes, and communication and documentation process.Conclusions\n\nThese adult guidelines will support the implementation of penicillin allergy delabeling programs in community and specialist centers in Australia. As high-level evidence supporting many recommendations in this field remains limited, a Delphi-based expert consensus approach provides valuable guidance.",
  "abstract_shown": true,
  "affiliations": [
    "National Allergy Council, Sydney, Australia.",
    "Medical School, The University of Western Australia, Perth, Australia.",
    "Australasian Society of Clinical Immunology and Allergy, Sydney, Australia.",
    "Sir Charles Gardiner Hospital, Perth, Australia.",
    "Perth Children's Hospital, Perth, Australia.",
    "Pathwest Laboratory Medicine, Perth, Australia.",
    "National Allergy Centre of Excellence, Melbourne, Australia.",
    "School of Population and Global Health, The University of Western Australia, Perth, Australia.",
    "School of Health and Clinical Sciences, The University of Western Australia, Perth, Australia.",
    "Murdoch Children's Research Institute, Melbourne, Australia.",
    "St Vincent's Hospital Sydney, Sydney, Australia.",
    "School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia.",
    "Child Health Research Centre, The University of Queensland, Brisbane, Australia.",
    "Department of Clinical Immunology and Allergy, Flinders Medical Centre, Adelaide, Australia.",
    "Austin Health, Melbourne, Australia.",
    "Royal North Shore Hospital, Sydney, Australia.",
    "Immunology Laboratory, Royal North Shore Hospital, New South Wales Health Pathology, Sydney, Australia.",
    "Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.",
    "Western Sydney University, Sydney, Australia.",
    "Campbelltown Hospital, Sydney, Australia.",
    "Peninsula University Hospital, Melbourne, Australia.",
    "Department of Anaesthesiology and Perioperative Medicine, Monash University, Melbourne, Australia.",
    "Department of Paediatrics, The University of Melbourne, Melbourne, Australia.",
    "Department of Allergy and Immunology, The Royal Children's Hospital, Melbourne, Australia.",
    "AllergySA, Adelaide, Australia.",
    "Royal Adelaide Hospital, Adelaide, Australia.",
    "Box Hill Hospital, Melbourne, Australia.",
    "Prince of Wales Hospital, Sydney, Australia.",
    "The University of New South Wales, Sydney, Australia."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 21,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3,
        4,
        5,
        6
      ],
      "name": "Michaela Lucas"
    },
    {
      "affs": [
        0
      ],
      "name": "Jillian Kehoe"
    },
    {
      "affs": [
        0,
        7
      ],
      "name": "Samantha Stiles"
    },
    {
      "affs": [
        6,
        8,
        9
      ],
      "name": "Sandra M Salter"
    },
    {
      "affs": [
        6,
        9,
        10,
        11
      ],
      "name": "Jacqueline Loprete"
    },
    {
      "affs": [
        6,
        9,
        12
      ],
      "name": "Catherine J Hornung"
    },
    {
      "affs": [
        2
      ],
      "name": "Lara Martin"
    },
    {
      "affs": [
        13
      ],
      "name": "Syed B Ali"
    },
    {
      "affs": [
        6,
        12
      ],
      "name": "Rani Scott Farmer"
    },
    {
      "affs": [
        14
      ],
      "name": "Joseph DeLuca"
    },
    {
      "affs": [
        15,
        16,
        17
      ],
      "name": "Suran Fernando"
    },
    {
      "affs": [
        18,
        19
      ],
      "name": "Constance Katelaris"
    },
    {
      "affs": [
        20,
        21
      ],
      "name": "Helen Kolawole"
    },
    {
      "affs": [
        6,
        14
      ],
      "name": "Jason Trubiano"
    },
    {
      "affs": [
        6,
        9,
        21,
        22,
        23
      ],
      "name": "Kirsten P Perrett"
    },
    {
      "affs": [
        0,
        2,
        24,
        25
      ],
      "name": "William Smith"
    },
    {
      "affs": [
        2,
        21,
        26
      ],
      "name": "Francis Thien"
    },
    {
      "affs": [
        6,
        9,
        12
      ],
      "name": "Jennifer J Koplin"
    },
    {
      "affs": [
        0,
        7
      ],
      "name": "Sandra Vale"
    },
    {
      "affs": [
        2,
        27,
        28
      ],
      "name": "James Yun"
    },
    {
      "name": "National Allergy Council Drug Allergy consortium∗"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/45vvys3h7tmd3.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jacig.2026.100784",
  "fulltext_url": "https://europepmc.org/articles/PMC13683019",
  "id": "45vvys3h7tmd3",
  "issns": [
    "2772-8293"
  ],
  "landing_url": "https://europepmc.org/article/MED/42908540",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2736|Drug-Induced Adverse Reactions"
    ]
  ],
  "openalex": "W7204591596",
  "pdf_url": "https://europepmc.org/articles/PMC13683019?pdf=render",
  "pmcid": "PMC13683019",
  "pmid": "42908540",
  "published": "2026-10-12",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/45vvys3h7tmd3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42908540",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42908540"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Drug-Induced Adverse Reactions",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Guidelines for the management of adult penicillin allergy in community and specialist settings in Australia and New Zealand: An AGREE II and Delphi-based approach.",
  "title_text": "Guidelines for the management of adult penicillin allergy in community and specialist settings in Australia and New Zealand: An AGREE II and Delphi-based approach.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/45vvys3h7tmd3",
  "venue": "The journal of allergy and clinical immunology. Global",
  "versions": []
}