{
  "abstract": "Purpose: This study aimed to investigate the association between peripapillary choroidal hemodynamics, as measured by laser speckle flowgraphy (LSFG), and systemic arterial stiffness, indicated by the cardio-ankle vascular index (CAVI), in patients with diabetic retinopathy (DR).\n\nMethods: In this retrospective cross-sectional study, 72 eyes from 72 patients with type 2 diabetes across DR stages were analyzed. Choroidal parameters, including mean blur rate (MBR; indicating blood flow), beat strength (BS; reflecting pulsatility), and the BS/MBR ratio (BOM; a resistance-related waveform index), were quantified in both temporal and nasal peripapillary regions. A stepwise multiple regression analysis was conducted to identify independent predictors of CAVI, considering age, sex, and LSFG parameters.\n\nResults: In univariate analyses, higher CAVI was significantly associated with increased choroidal pulsatility and resistance (P < 0.05). In the final exploratory stepwise multivariable model, age remained significantly associated with higher CAVI (β = 0.048, P = 0.020), while temporal BOM showed a borderline positive trend with CAVI (β = 2.719, P = 0.055). The model was statistically significant overall (adjusted R² = 0.326, P < 0.001).\n\nConclusions: In patients with DR, age was the most robust determinant of CAVI. The retention of regional choroidal BOM parameters in the final exploratory stepwise model suggests a possible association whereby systemic pulsatile stress may influence choroidal hemodynamics, although these findings are exploratory and hypothesis-generating.\n\nTranslational Relevance: LSFG-derived choroidal resistance (BOM) may help explore the ocular–systemic vascular connection in diabetes management.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Ophthalmology, Toho University Graduate School of Medicine, Tokyo, Japan",
    "Department of Ophthalmology, Toho University Sakura Medical Center, Chiba, Japan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Naoki Fujioka"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Kazufumi Tanaka"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Moe Nunose"
    },
    {
      "affs": [
        1
      ],
      "name": "Sara Imai"
    },
    {
      "affs": [
        1
      ],
      "name": "Ryota Takenaka"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Fumihiko Yagi"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuichi Hori"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ryuya Hashimoto"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/462wxvp3w8p80.bib",
  "cited_by": 0,
  "doi": "10.1167/tvst.15.10.41",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13722980/",
  "id": "462wxvp3w8p80",
  "issns": [
    "2164-2591"
  ],
  "landing_url": "https://doi.org/10.1167/tvst.15.10.41",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Retina"
    ],
    [
      "openalex",
      "2731|Retinal Diseases and Treatments"
    ]
  ],
  "openalex": "W7223696224",
  "pdf_url": null,
  "pmcid": "PMC13722980",
  "pmid": "42929703",
  "published": "2026-10-26",
  "publisher": "Association for Research in Vision and Ophthalmology",
  "ris": "https://research.draconitic.com/paper/462wxvp3w8p80.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:40Z",
      "native_id": "PMC13722980",
      "source": "pmc",
      "url": "https://doi.org/10.1167/tvst.15.10.41"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2731|Retinal Diseases and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Association Between Systemic Arterial Stiffness and Choroidal Vascular Resistance Assessed by Laser Speckle Flowgraphy in Diabetic Retinopathy",
  "title_text": "Association Between Systemic Arterial Stiffness and Choroidal Vascular Resistance Assessed by Laser Speckle Flowgraphy in Diabetic Retinopathy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:40Z",
  "url": "https://research.draconitic.com/paper/462wxvp3w8p80",
  "venue": "Translational Vision Science & Technology",
  "versions": []
}