{
  "abstract": "Background: Renal abnormalities are common in patients with cancer and may result from the malignancy itself, associated comorbidities, urinary obstruction, or anticancer supportive treatments. This study aimed to determine the spectrum of renal disorders among patients with solid malignancies and assess factors associated with acute kidney injury (AKI)chronic kidney disease (CKD). Methods: This cross-sectional observational study included 100 adults with confirmed solid malignancies. Clinical assessment, renal function tests, serum electrolytes, urinary albumin-to-creatinine ratio (UACR), arterial blood gases, urinalysis, and pelvi-abdominal ultrasonography were evaluated. Renal disorders were classified as acute kidney injury (AKI), chronic kidney disease (CKD), obstructive nephropathy, electrolyte imbalance, albuminuria, or mixed renal abnormalities. Regression analysis was performed to identify factors independently associated with AKI and CKD. Results: Renal involvement was identified in 90% of patients. AKI was the most frequent disorder (28%), followed by CKD (22%), obstructive nephropathy (13%), electrolyte imbalance (10%), mixed abnormalities (9%), and albuminuria (8%). Serum creatinine (P=0.01), uric acid (P=0.03), kidney size (P=0.04), and hematuria (P=0.02) differed significantly between malignancy groups. The overall renal disorder pattern showed no significant association with malignancy type (P=0.91) or treatment modality (P=0.25). Serum potassium (OR=8.84, P=0.001), phosphorus (OR=3.81, P=0.009), and UACR (OR=1.04, P=0.002) independently predicted AKI. Older age, diabetes mellitus, hypertension, and UACR independently predicted CKD. Conclusion: Renal abnormalities were highly prevalent among patients with solid malignancies, with AKI and CKD representing the predominant disorders. Renal risk appeared to be more strongly related to metabolic abnormalities, albuminuria, and cardiometabolic comorbidities than to tumor type or treatment modality",
  "abstract_shown": true,
  "affiliations": [
    "Professor of Internal Medicine, Faculty of Medicine, Zagazig University",
    "Professor of Clinical Oncology, Faculty of Medicine, Zagazig University",
    "Resident of Internal Medicine, Faculty of Medicine, Zagazig University",
    "Lecturer of Internal Medicine, Faculty of Medicine, Zagazig University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Alsayed Alnahal"
    },
    {
      "affs": [
        1
      ],
      "name": "Abd El Motaleb Mohamed"
    },
    {
      "affs": [
        0
      ],
      "name": "Niveen Sakla"
    },
    {
      "affs": [
        2
      ],
      "name": "Amany Sleim"
    },
    {
      "affs": [
        3
      ],
      "name": "Mohammed Abdel Moniem"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/46njepg1z1t3w.bib",
  "cited_by": 0,
  "doi": "10.21608/zumj.2026.526970.4809",
  "fulltext_url": "https://zumj.journals.ekb.eg/article_533950.html",
  "id": "46njepg1z1t3w",
  "issns": [
    "2357-0717",
    "1110-1431"
  ],
  "landing_url": "https://doi.org/10.21608/zumj.2026.526970.4809",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R5-920"
    ],
    [
      "openalex",
      "2740|Renal cell carcinoma treatment"
    ]
  ],
  "openalex": "W7222877936",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-25",
  "publisher": "Zagazig University, Faculty of Medicine",
  "ris": "https://research.draconitic.com/paper/46njepg1z1t3w.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:09Z",
      "native_id": "fca4e2cf00cf4d27ad26f5b32082656d",
      "source": "doaj",
      "url": "https://doi.org/10.21608/zumj.2026.526970.4809"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Renal cell carcinoma treatment",
      "subfield": "general"
    }
  ],
  "title": "Spectrum of Renal Disorders in Patients with Solid Malignancies: A Cross-Sectional Study",
  "title_text": "Spectrum of Renal Disorders in Patients with Solid Malignancies: A Cross-Sectional Study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:09Z",
  "url": "https://research.draconitic.com/paper/46njepg1z1t3w",
  "venue": "Zagazig University Medical Journal",
  "versions": []
}