{
  "abstract": "Ultraviolet (UV)-induced photodamage drives oxidative stress, DNA damage, and chronic inflammation, leading to progressive cellular ultrastructure and skin function degeneration. Despite the potential of probiotics as anti-photodamage agents, their nanoscale action mechanism remains unexplored. Here, we utilize super-resolution fluorescence microscopy to investigate the cellular and molecular basis of Lactobacillus plantarum-derived extracellular vesicles (L. plantarum EVs) in mitigating photodamage. We showed that UV irradiation triggered extensive organellar remodeling along with elevated reactive oxygen species production, DNA damage signaling, and inflammatory activation. Remarkably, pre- and posttreatment with L. plantarum EVs preserved organelle integrity and restored native nanoscale architecture. Additionally, EV treatment delayed UV-induced PARP-1 activation and nuclear condensate clustering, while suppressing NF-κB translocation and downstream inflammatory cytokine expression. These findings establish probiotic-derived EVs as modulators of stress-responsive signaling and structural homeostasis during UV-induced photodamage. By providing a super-resolution mechanistic framework for understanding probiotic EV-mediated modulation of cellular photodamage responses, this study provides a basis for future investigation of EV-based strategies for skin protection.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, Hanyang University, Seoul 04763, Republic of Korea.",
    "Center for Bio-imaging & Translational Research, Korea Basic Science Institute, Cheongju 28119, Republic of Korea.",
    "R&D Institute, LG Household & Health Care (LG H&H), Seoul 07795, Republic of Korea.",
    "Research Institute for Convergence of Basic Science, Hanyang University, Seoul 04763, Republic of Korea.",
    "Institute of Nano Science and Technology, Hanyang University, Seoul 04763, Republic of Korea.",
    "Research Institute for Natural Sciences, Hanyang University, Seoul 04763, Republic of Korea."
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ga-eun Go",
      "orcid": "0009-0005-2034-3320"
    },
    {
      "affs": [
        0
      ],
      "name": "Seungju Han",
      "orcid": "0009-0002-8456-0023"
    },
    {
      "affs": [
        0
      ],
      "name": "Minjae Kang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Sangoh Choi"
    },
    {
      "affs": [
        0
      ],
      "name": "Soo-eun Lee",
      "orcid": "0009-0002-6334-2422"
    },
    {
      "affs": [
        0
      ],
      "name": "Uidon Jeong",
      "orcid": "0000-0003-4799-2660"
    },
    {
      "affs": [
        1
      ],
      "name": "Sang-Hee Lee"
    },
    {
      "affs": [
        2
      ],
      "name": "Ki-Nam Gu",
      "orcid": "0000-0002-3445-644X"
    },
    {
      "affs": [
        2
      ],
      "name": "Hanji Kim",
      "orcid": "0000-0001-9635-6084"
    },
    {
      "affs": [
        2
      ],
      "name": "Bo Kyoung Hwang",
      "orcid": "0009-0009-2080-2602"
    },
    {
      "affs": [
        2
      ],
      "name": "Yunkwan Kim",
      "orcid": "0000-0003-1353-4784"
    },
    {
      "affs": [
        2
      ],
      "name": "Euitaek Jeong",
      "orcid": "0000-0003-4877-3873"
    },
    {
      "affs": [
        2
      ],
      "name": "Nae-Gyu Kang",
      "orcid": "0000-0002-3318-3873"
    },
    {
      "affs": [
        0,
        3,
        4,
        5
      ],
      "name": "Doory Kim",
      "orcid": "0000-0002-2675-106X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/476rjfh3hyjej.bib",
  "cited_by": 0,
  "doi": "10.1126/sciadv.aek5197",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13721989/?tool=EBI",
  "id": "476rjfh3hyjej",
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  "landing_url": "https://www.science.org/doi/abs/10.1126/sciadv.aek5197",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Biomedicine and Life Sciences"
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    [
      "heading",
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    [
      "heading",
      "Microbiology"
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      "heading",
      "Research Article"
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  "openalex": null,
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13721989/pdf/?tool=EBI",
  "pmcid": "PMC13721989",
  "pmid": "42962041",
  "published": "2026-10-30",
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "ris": "https://research.draconitic.com/paper/476rjfh3hyjej.ris",
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  "subjects": [
    {
      "field": "biochemistry",
      "origin": "heading:Biophysics",
      "subfield": "biophysics"
    },
    {
      "field": "biology",
      "origin": "heading:Microbiology",
      "subfield": "microbiology"
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  ],
  "title": "Super-resolution mapping of nuclear stress signaling by probiotic-derived extracellular vesicles in UV-induced skin photodamage",
  "title_text": "Super-resolution mapping of nuclear stress signaling by probiotic-derived extracellular vesicles in UV-induced skin photodamage",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:35Z",
  "url": "https://research.draconitic.com/paper/476rjfh3hyjej",
  "venue": "Science Advances",
  "versions": []
}