{
  "abstract": "ROR{gamma}t, encoded by Rorc, is a key transcriptional regulator of T helper 17 (Th17) cell differentiation, and IL-17A signaling has been implicated in neural development and behavior. We examined behavioral phenotypes in male ROR{gamma}t-transgenic mice with T-cell-biased ROR{gamma}t overexpression and their wild-type littermates. Mice were assessed using the resident-intruder paradigm and the light-dark box test, followed by body-weight measurement. ROR{gamma}t-transgenic mice had significantly lower body weight than wild-type mice. No genotype differences were detected in attack latency, attack frequency, light-compartment occupancy, light-dark transitions, or transition latency. In contrast, analysis of locomotor activity in 1-min bins revealed a significant genotype x time interaction. Transgenic mice showed nominally reduced locomotor activity during the first minute of the light-dark box test, although this single-bin comparison did not remain significant after correction for multiple comparisons. These findings indicate that T-cell-biased ROR{gamma}t overexpression is associated with altered temporal dynamics of locomotor activity in a novel environment rather than a generalized anxiety-like or aggression-related phenotype.",
  "abstract_shown": true,
  "affiliations": [
    "Laboratory of Anatomy and Neuroscience, Department of Biomedical Sciences, Institute of Medicine, University of Tsukuba"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "T. Sasaki"
    },
    {
      "name": "A. Takahashi"
    },
    {
      "name": "Y. Takei"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/47gewf34z21mc.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.08.31.748441",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.08.31.748441v1.full",
  "id": "47gewf34z21mc",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.08.31.748441v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "animal behavior and cognition"
    ],
    [
      "openalex",
      "2403|Psoriasis: Treatment and Pathogenesis"
    ]
  ],
  "openalex": "W7208749211",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.08.31.748441v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-31",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/47gewf34z21mc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:23Z",
      "native_id": "10.64898/2026.08.31.748441",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.08.31.748441v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:animal behavior and cognition",
      "subfield": "zoology-behaviour"
    }
  ],
  "title": "Male RORγt-transgenic mice exhibit lower body weight and an altered locomotor response to a novel environment",
  "title_text": "Male RORγt-transgenic mice exhibit lower body weight and an altered locomotor response to a novel environment",
  "type": "preprint",
  "updated_at": "2026-10-30T12:19:23Z",
  "url": "https://research.draconitic.com/paper/47gewf34z21mc",
  "venue": "bioRxiv",
  "versions": []
}