{
  "abstract": "Background\n\nPreoperative sarcopenia and frailty are associated with poor outcomes in elderly patients undergoing cardiac surgery; this study aimed to investigate the effects of sarcopenia and frailty on postoperative recovery in elderly patients.Methods\n\nThis prospective cohort study included 566 patients aged ≥60 years with an American Society of Anaesthesiologists (ASA) II-IV status who were scheduled for elective open-heart surgery between June 30, 2024, and April 5, 2026. Frailty was assessed using the Comprehensive Geriatric Assessment Frailty Index (CGA-FI). Sarcopenia was diagnosed based on the CT-based skeletal muscle index (SMI), grip strength, and physical function. The primary outcome was worsening disability or death within 3 months after surgery.A multivariate logistic regression model was used to estimate the association of sarcopenia and/or frailty with worsening disability or death within 3 months after surgery.Results\n\nPatients with sarcopenia and frailty did not experience a reduction in disability burden within 3 months postoperatively [-2.0 (IQR: -9.0, 21.2)]. In contrast, patients with sarcopenia only and those with frailty only had significant reductions in the overall disability burden [-5.0 (IQR: -7.0, 0.0) and -5.0 (IQR: -8.0, -1.0)]. Compared with normal patients, those with both sarcopenia and frailty (OR = 3.09; 95% CI 1.61-5.96), those with sarcopenia only (OR = 2.65; 95% CI 1.38-5.12), and those with frailty only (OR 1.93; 95% CI 1.01-3.72) had a significantly increased risk of worsening disability or death within 3 months post-surgery.Conclusion\n\nFrailty, sarcopenia, and their combination are associated with a significantly increased risk of worsening disability or death within 3 months after surgery. Notably, compared with patients with both sarcopenia and frailty, those with frailty alone or sarcopenia alone have a lower burden of postoperative disability.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anesthesiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China; Institute of Anesthesiology, Soochow University, Suzhou, Jiangsu, People's Republic of China.",
    "Department of Intensive Care Medicine, Affiliated Hospital of Xuzhou Medical University, 99 Huaihai West Road, Xuzhou City, 221006, People's Republic of China.",
    "Department of Intensive Care Medicine, Affiliated Hospital of Xuzhou Medical University, 99 Huaihai West Road, Xuzhou City, 221006, People's Republic of China. Electronic address: fgl3480535933@163.com.",
    "Department of Anesthesiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China; Institute of Anesthesiology, Soochow University, Suzhou, Jiangsu, People's Republic of China. Electronic address: lingximxw@163.com.",
    "Department of Anesthesiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China; Institute of Anesthesiology, Soochow University, Suzhou, Jiangsu, People's Republic of China. Electronic address: jifuhai@suda.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Guanglei Fan"
    },
    {
      "affs": [
        0
      ],
      "name": "Yang Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Guoqiang Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Wanzhou Wang"
    },
    {
      "affs": [
        2
      ],
      "name": "Wenjing Zhao"
    },
    {
      "affs": [
        3
      ],
      "name": "Xiaowen Meng"
    },
    {
      "affs": [
        4
      ],
      "name": "Fuhai Ji"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/47hn5f7h1pvat.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jnha.2026.101003",
  "fulltext_url": "https://europepmc.org/articles/PMC13677951",
  "id": "47hn5f7h1pvat",
  "issns": [
    "1760-4788"
  ],
  "landing_url": "https://europepmc.org/article/MED/42854514",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2717|Frailty in Older Adults"
    ]
  ],
  "openalex": "W7221119375",
  "pdf_url": "https://europepmc.org/articles/PMC13677951?pdf=render",
  "pmcid": "PMC13677951",
  "pmid": "42854514",
  "published": "2026-10-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/47hn5f7h1pvat.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:12Z",
      "native_id": "MED:42854514",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42854514"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2717|Frailty in Older Adults",
      "subfield": "general"
    }
  ],
  "title": "Impact of preoperative frailty and sarcopenia on short-term functional recovery after cardiac surgery in elderly patients: a prospective cohort study.",
  "title_text": "Impact of preoperative frailty and sarcopenia on short-term functional recovery after cardiac surgery in elderly patients: a prospective cohort study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:12Z",
  "url": "https://research.draconitic.com/paper/47hn5f7h1pvat",
  "venue": "The journal of nutrition, health & aging",
  "versions": []
}