{
  "abstract": "The respiratory syncytial virus (RSV) causes fatal pneumonia in neonates, infants, and older adults. However, no approved antiviral drugs exist for RSV; furthermore, the currently available antibody-based therapies are expensive and do not provide complete protection against RSV infections. Thus, developing anti-RSV agents for treating RSV infections is crucial. We previously established a rational strategy for designing peptide-based fusion inhibitors targeting class I fusion proteins, which are essential for the membrane fusion of viruses and host cells. Here, we used this strategy to identify peptide-based fusion inhibitors that block the interaction between the heptad repeat 1 and 2 (HR1 and -2) regions of the RSV F protein and identified four key amino acid regions involved in the HR1–HR2 interaction. Peptides, including the key amino acid regions VirRS2 and VirRS8, inhibited the replication of the RSV-A2 strain. We confirmed the structure–activity relationships using crystal structure coordinates and AlphaFold2-based structural predictions. These results may advance novel RSV fusion inhibitor development.",
  "abstract_shown": true,
  "affiliations": [
    "Tohoku University Graduate School of Medicine , , 2-1 Seiryo-machi , Aoba-ku, , ,",
    "Japan Institute for Health Security , , , ,",
    "Kyoto Pharmaceutical University , , 1 Misasagi-Shichono-cho , Yamashina-ku, ,",
    "Kyoto University , , 46-29 Yoshida-Shimo-Adachi-cho , Sakyo-ku, ,",
    "Fukushima Medical University , , 1 Hikariga-oka , , ,",
    "Tohoku University , , 2-1 Seiryo-machi , Aoba-ku, , ,",
    "Emory University School of Medicine , , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Satoshi Suzuki",
      "orcid": "0000-0002-5122-0180"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Yusuke Usui"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Keisuke Aoki"
    },
    {
      "affs": [
        2
      ],
      "name": "Haruto Amano"
    },
    {
      "affs": [
        0
      ],
      "name": "Yoshiki Hiramatsu"
    },
    {
      "affs": [
        0
      ],
      "name": "Akie Nishiyama"
    },
    {
      "affs": [
        4
      ],
      "name": "Koichi Hashimoto"
    },
    {
      "affs": [
        5
      ],
      "name": "Kazutaka Murayama",
      "orcid": "0000-0003-1749-4038"
    },
    {
      "affs": [
        5
      ],
      "name": "Hironori Hayashi"
    },
    {
      "affs": [
        6
      ],
      "name": "Stefan G. Sarafianos"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Shinya Oishi",
      "orcid": "0000-0002-2833-2539"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Eiichi N. Kodama",
      "orcid": "0000-0002-6622-2752"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/47xxvvaja6496.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.6c05253",
  "fulltext_url": "https://europepmc.org/articles/PMC13689203",
  "id": "47xxvvaja6496",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://pubs.acs.org/acsodf/article/11/41/63006/5446588/Potent-Antivirals-for-Respiratory-Syncytial-Virus",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Respiratory viral infections research"
    ]
  ],
  "openalex": "W7220846076",
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/acsomega.6c05253",
  "pmcid": "PMC13689203",
  "pmid": "42924144",
  "published": "2026-10-07",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/47xxvvaja6496.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:39Z",
      "native_id": "10.1021/acsomega.6c05253",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/11/41/63006/5446588/Potent-Antivirals-for-Respiratory-Syncytial-Virus"
    },
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42924144",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42924144"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Respiratory viral infections research",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Potent Antivirals for Respiratory Syncytial Virus Detected via Peptide-Based Fusion Inhibitor Screening",
  "title_text": "Potent Antivirals for Respiratory Syncytial Virus Detected via Peptide-Based Fusion Inhibitor Screening",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/47xxvvaja6496",
  "venue": "ACS Omega",
  "versions": []
}