{
  "abstract": "Reductive functionalization of nitrogen-bearing carboxylic acid derivatives represents a powerful yet underexplored platform for assembling value-added nitrogen heterocycles. Herein, we describe an iridium-catalyzed unified reductive manifold that converts acyclic hydrazides into pyrroles and indoles under acid-free conditions. This transformation realizes sigmatropic rearrangement via in-situ formed N,N’-dialkyl bisvinylhydrazine intermediates, circumventing key limitations of classic Piloty-Robinson and Fischer syntheses. Excellent functional-group compatibility and scale-up capability underscore its potential to expand the synthetic toolbox for carboxylic-derived nitrogen-containing molecules.",
  "abstract_shown": true,
  "affiliations": [
    "School of Chemistry",
    "Sun Yat-sen University",
    "College of Light Chemical Industry and Materials Engineering",
    "Shunde Polytechnic University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ruizhi Yang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Changshu Wu"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Qiu Shi"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Wenbo H. Liu",
      "orcid": "0000-0001-8442-2697"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/486tyxr3j4akc.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15010696/v1",
  "fulltext_url": null,
  "id": "486tyxr3j4akc",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010696/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Synthesis and Characterization of Pyrroles"
    ]
  ],
  "openalex": "W7223069791",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010696/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-20",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/486tyxr3j4akc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.26434/chemrxiv.15010696",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010696/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Synthesis and Characterization of Pyrroles",
      "subfield": "organic"
    }
  ],
  "title": "Unified reductive synthesis of pyrrole and indole under acid-free conditions",
  "title_text": "Unified reductive synthesis of pyrrole and indole under acid-free conditions",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/486tyxr3j4akc",
  "venue": "ChemRxiv",
  "versions": []
}