{
  "abstract": "Objective: Insulin resistance (IR) plays a pivotal role in the pathogenesis of atrial fibrillation (AF). The novel cholesterol-high-density lipoprotein-glucose (CHG) index, which integrates total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and fasting blood glucose (FBG), has not been validated for predicting AF recurrence following radiofrequency catheter ablation (RFCA). This study aimed to evaluate the association between the CHG index and 1-year AF recurrence after RFCA, and to compare its performance with the triglyceride-glucose (TyG) index.\n\nMethods: A retrospective cohort of 813 AF patients who underwent first-time RFCA was enrolled. The primary outcome was any atrial tachyarrhythmia lasting ≥ 30 s after a 3-month blanking period. Cox regression, ROC curve, net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were used to assess predictive performance.\n\nResults: During 1-year follow-up, 142 patients (17.5%) had recurrent atrial tachyarrhythmia, with significantly higher CHG levels in the recurrence group ( P < 0.001). Each unit increase in the CHG index was associated with a 4.23-fold higher risk of recurrence (HR = 4.231, 95% CI: 3.406–5.257, P < 0.001). The restricted cubic spline curve shows a dose-response relationship between CHG and AF recurrence. The CHG index yielded an AUC of 0.765, superior to TyG (AUC = 0.673). Adding the CHG index to the traditional risk model significantly improved NRI (0.434, P < 0.001) and IDI (0.200, P < 0.001), with greater improvement than adding the TyG index. Subgroup analyses demonstrated consistent predictive effects across different populations.\n\nConclusions: The CHG index is an independent risk marker for 1-year recurrence after AF ablation and demonstrates superior discriminative ability compared to the TyG index.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University",
    "Department of Outpatient Internal Medicine, Affiliated Children’s Hospital of Xi'an Jiaotong University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kamila Kamili"
    },
    {
      "affs": [
        0
      ],
      "name": "Suining Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiyang Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Danni Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Pengjie Gao"
    },
    {
      "affs": [
        0
      ],
      "name": "Gang Tian"
    },
    {
      "affs": [
        1
      ],
      "name": "Haijian Xing"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/486wxzvb0rkvg.bib",
  "cited_by": 0,
  "doi": "10.3389/fcvm.2026.1982137",
  "fulltext_url": null,
  "id": "486wxzvb0rkvg",
  "issns": [
    "2297-055X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fcvm.2026.1982137/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/486wxzvb0rkvg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "10.3389/fcvm.2026.1982137",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fcvm.2026.1982137/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2297-055X",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Novel cholesterol-high-density lipoprotein-glucose index is associated with 1-year recurrence of atrial fibrillation after catheter ablation",
  "title_text": "Novel cholesterol-high-density lipoprotein-glucose index is associated with 1-year recurrence of atrial fibrillation after catheter ablation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T00:21:07Z",
  "url": "https://research.draconitic.com/paper/486wxzvb0rkvg",
  "venue": "Frontiers in Cardiovascular Medicine",
  "versions": []
}