{
  "abstract": "A high-fat diet is associated with metabolic disorder, including obesity, insulin resistance, dyslipidemia, and hypertension. Polysaccharides derived from mushrooms have attracted interest for their potential metabolic and anti-inflammatory effects. Nevertheless, the impact of crude polysaccharides derived from the Lentinula edodes (Berk.) Pegler (PSC) on metabolic conditions linked to high-fat diets remains insufficiently studied. This study aimed to evaluate the bioactivity of PSC obtained using ultrasound-water extraction (UW) on metabolic parameters, hepatic function, and inflammation in rats fed a high-fat diet (HFD). Male Wistar rats (5 weeks old, 180-200 g; n = 6 per group) were assigned to normal-diet (ND) or high-fat-diet (HFD) groups, with or without PSC administration. PSC was administered by oral gavage at 400 mg/kg body weight/day for 4 weeks. Compared with the HFD group at week 20, the HFD+PSC group showed 30.44% lower body-weight gain, while LDL-C, AST, ALT, and IL-6 levels were 42.31%, 35.77%, 55.15%, and 41.78% lower. Histopathological examination showed reduced hepatic steatosis and inflammatory alterations following PSC extract administration, with the NAS decreasing from 5.60 ± 0.51 in the HFD group to 2.00 ± 0.32 in the PSC extract administration. The findings indicate that a PSC extract decreased various metabolic, hepatic, and inflammatory changes correlated with HFD. This study supports the potential of PSC extract as a mushrooms-derived functional ingredient to improve metabolic function.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Food Science and Technology, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Nannapat Phosarith",
      "orcid": "0009-0000-5825-7851"
    },
    {
      "affs": [
        0
      ],
      "name": "Thanyaporn Siriwoharn",
      "orcid": "0000-0001-9060-3662"
    },
    {
      "affs": [
        0
      ],
      "name": "Wachira Jirarattanarangsri",
      "orcid": "0000-0001-6059-024X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/48c5048c5j14p.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27198631",
  "fulltext_url": "https://europepmc.org/articles/PMC13665417",
  "id": "48c5048c5j14p",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://europepmc.org/article/MED/42883879",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2736|Fungal Biology and Applications"
    ]
  ],
  "openalex": "W7214596302",
  "pdf_url": "https://europepmc.org/articles/PMC13665417?pdf=render",
  "pmcid": "PMC13665417",
  "pmid": "42883879",
  "published": "2026-09-26",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/48c5048c5j14p.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42883879",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42883879"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Fungal Biology and Applications",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Effects of Crude Polysaccharides from Lentinula edodes Obtained by Ultrasound-Assisted Water Extraction on Metabolic and Hepatic Parameters in Obese Rats.",
  "title_text": "Effects of Crude Polysaccharides from Lentinula edodes Obtained by Ultrasound-Assisted Water Extraction on Metabolic and Hepatic Parameters in Obese Rats.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/48c5048c5j14p",
  "venue": "International journal of molecular sciences",
  "versions": []
}