{
  "abstract": "Dietary restrictions are increasingly recognized as modulators of immune cell function. However, how they shape CD8⁺ T cell fate decisions remains incompletely understood. Here, we investigated the impact of intermittent fasting (IF) on differentiation of heterogeneous effector T cell subsets and the formation of a long-lived homeostatic memory pool. We found that IF skewed CD8⁺ T cell differentiation toward memory precursor effector cells (MPECs) and enhanced the central memory CD8⁺ T cell development and functions. Mechanistically, glucose restriction induced by IF promotes alternative metabolic fluxes leading to fatty acid oxidation. This metabolic shift enhanced mitochondrial fitness and supported MPEC differentiation via metabolic-epigenetic cross-talk, culminating in durable and functionally robust memory CD8⁺ T cell responses. Applying this strategy in adoptive transfer therapy, intratumoral defects could be circumvented by imprinting a memory phenotype under IF-mimicking conditions, resulting in improved and long-lasting antitumor activity. Collectively, these findings underscore the importance of IF in orchestrating metabolic-epigenetic cross-talk to enhance memory formation and antitumor immunity.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Agricultural Biotechnology, and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea.",
    "The Gene Lay Institute of Immunology and Inflammation, Harvard Medical School and Brigham and Women’s Hospital, Boston, USA.",
    "Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.",
    "Department of Oral Microbiology and Immunology, and Dental Research Institute, School of Density, Seoul National University, Seoul 08826, Republic of Korea.",
    "Department of Microbiology and Immunology and Medical Research Center for Combinatorial Tumor Immunotherapy, Chonnam National University Medical School, Hwasun 58128, Republic of Korea.",
    "Institutes of Green Bio Science & Technology, Seoul National University, Pyeongchang 25354, Republic of Korea.",
    "Center for Food and Bioconvergence, Seoul National University, Seoul 08826, Republic of Korea."
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Da-Jeong Park",
      "orcid": "0000-0002-0560-0158"
    },
    {
      "affs": [
        1
      ],
      "name": "Young-Jun Ju",
      "orcid": "0000-0002-7561-0677"
    },
    {
      "affs": [
        0
      ],
      "name": "Young Jin Pyung",
      "orcid": "0000-0001-8313-8475"
    },
    {
      "affs": [
        0
      ],
      "name": "Cheol Gyun Kim",
      "orcid": "0009-0007-8384-037X"
    },
    {
      "affs": [
        0
      ],
      "name": "Narae Kim",
      "orcid": "0000-0003-4216-0857"
    },
    {
      "affs": [
        2
      ],
      "name": "MinJi Lim",
      "orcid": "0009-0000-1828-6324"
    },
    {
      "affs": [
        2
      ],
      "name": "Hyungseok Seo",
      "orcid": "0000-0002-6632-1208"
    },
    {
      "affs": [
        3
      ],
      "name": "Seung Hyun Han",
      "orcid": "0000-0001-9418-9278"
    },
    {
      "affs": [
        4
      ],
      "name": "Jae-Ho Cho",
      "orcid": "0000-0002-3081-7674"
    },
    {
      "affs": [
        0,
        5,
        6
      ],
      "name": "Cheol-Heui Yun",
      "orcid": "0000-0002-0041-2887"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/48en9jrfq5m19.bib",
  "cited_by": 0,
  "doi": "10.1126/sciadv.aeg0361",
  "fulltext_url": "https://europepmc.org/articles/PMC13715723",
  "id": "48en9jrfq5m19",
  "issns": [
    "2375-2548"
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  "landing_url": "https://www.science.org/doi/abs/10.1126/sciadv.aeg0361",
  "language": "eng",
  "licence": "CC-BY-NC",
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  "native_subjects": [
    [
      "heading",
      "Biomedicine and Life Sciences"
    ],
    [
      "heading",
      "Immunology"
    ],
    [
      "heading",
      "Research Article"
    ],
    [
      "heading",
      "SciAdv r-articles"
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    [
      "openalex",
      "2737|Dietary Effects on Health"
    ]
  ],
  "openalex": "W7224131348",
  "pdf_url": "https://europepmc.org/articles/PMC13715723?pdf=render",
  "pmcid": "PMC13715723",
  "pmid": "42950055",
  "published": "2026-10-28",
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "ris": "https://research.draconitic.com/paper/48en9jrfq5m19.ris",
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  "subjects": [
    {
      "field": "biology",
      "origin": "heading:Immunology",
      "subfield": "immunology"
    }
  ],
  "title": "Glucose restriction induced by intermittent fasting promotes alternative metabolic fluxes leading to memory CD8+ T cell development",
  "title_text": "Glucose restriction induced by intermittent fasting promotes alternative metabolic fluxes leading to memory CD8+ T cell development",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:56Z",
  "url": "https://research.draconitic.com/paper/48en9jrfq5m19",
  "venue": "Science Advances",
  "versions": []
}