{ "abstract": "Deep brain stimulation (DBS) is an emerging therapeutic option for treatment resistant neurological and psychiatric disorders, most notably depression. Despite this, little is known about the anatomical and functional mechanisms that underlie this therapy. Here we targeted stimulation to the white matter adjacent to the subcallosal anterior cingulate cortex (SCC-DBS) in macaques, modeling the location in the brain proven effective for depression. We demonstrate that SCC-DBS has a selective effect on white matter macro- and micro-structure in the cingulum bundle distant to where stimulation was delivered. SCC-DBS also decreased functional connectivity between subcallosal and posterior cingulate cortex, two areas linked by the cingulum bundle and implicated in depression. Our data reveal that white matter remodeling as well as functional effects contribute to DBS’s therapeutic efficacy.", "abstract_shown": true, "affiliations": [ "Department of Neuroscience and Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA. sfujimot@umn.edu", "Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. sfujimot@umn.edu", "Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. sfujimot@umn.edu", "Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai", "Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai", "New York, NY 1009, USA", "Department of Neuroscience and Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA", "Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA", "Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA", "BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai", "Nash Family Center for Advanced Circuit Therapeutics, Mount Sinai West Hospital", "New York, NY 10029, USA", "BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA", "Nash Family Center for Advanced Circuit Therapeutics, Mount Sinai West Hospital, New York, NY, USA", "New York, NY 0029, USA", "Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute", "Department of Psychiatry, New York University at Langone", "Orangeburg, NY 10962, USA", "Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute, Orangeburg, NY, USA", "Department of Psychiatry, New York University at Langone, New York, NY, USA", "Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. peter.rudebeck@mssm.edu", "Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. peter.rudebeck@mssm.edu" ], "article_type": null, "arxiv": null, "author_total": 14, "authors": [ { "affs": [ 0, 1, 2, 3, 4, 5 ], "name": "Satoka H. Fujimoto", "orcid": "0000-0003-2374-3002" }, { "affs": [ 6, 7, 8, 3, 4, 5 ], "name": "Atsushi Fujimoto", "orcid": "0000-0002-1621-2003" }, { "affs": [ 7, 8, 3, 4, 5 ], "name": "Catherine Elorette", "orcid": "0000-0001-5735-4369" }, { "affs": [ 7, 8, 3, 4, 5 ], "name": "Adela Seltzer" }, { "affs": [ 7, 8, 3, 4, 5 ], "name": "Emma Andraka", "orcid": "0000-0002-3013-2384" }, { "affs": [ 7, 8, 9, 10, 11 ], "name": "Keondre Herbert", "orcid": "0009-0006-4539-9301" }, { "affs": [ 12, 13, 4, 14 ], "name": "Gaurav Verma", "orcid": "0000-0002-7157-439X" }, { "affs": [ 8, 9, 11 ], "name": "William G.M. Janssen", "orcid": "0000-0003-3954-7866" }, { "affs": [ 12, 3, 4, 5 ], "name": "Lazar Fleysher", "orcid": "0000-0002-8727-2572" }, { "affs": [ 7, 8, 9, 10, 11 ], "name": "Davide Folloni", "orcid": "0000-0003-1653-5969" }, { "affs": [ 12, 13, 15, 16, 4, 14, 17 ], "name": "Ki Sueng Choi", "orcid": "0000-0002-6446-0677" }, { "affs": [ 18, 19, 8, 10, 4, 14 ], "name": "Brian Edward Russ", "orcid": "0000-0003-0320-1257" }, { "affs": [ 13, 8, 3, 4, 5 ], "name": "Helen S. Mayberg", "orcid": "0000-0002-1672-2716" }, { "affs": [ 20, 21 ], "name": "Peter H. Rudebeck", "orcid": "0000-0002-1411-7555" } ], "bibtex": "https://research.draconitic.com/paper/48fbbpyhaxrap.bib", "cited_by": 16, "doi": "10.1038/s41593-026-02301-4", "fulltext_url": null, "id": "48fbbpyhaxrap", "issns": [ "1097-6256", "1546-1726" ], "landing_url": "https://doi.org/10.1038/s41593-026-02301-4", "language": "en", "licence": "CC-BY-NC-ND", "licence_label": "CC BY-NC-ND", "licence_source": "journal", "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "metadata_licence": null, "native_subjects": [ [ "openalex", "2728|Deep Brain Stimulation and Movement Disorders" ], [ "openalex", "2728|Neurological disorders and treatments" ] ], "openalex": "W4399708873", "pdf_url": null, "pmcid": "PMC11195276", "pmid": "38915600", "published": "2026-06-01", "publisher": "Nature Portfolio", "ris": "https://research.draconitic.com/paper/48fbbpyhaxrap.ris", "sources": [ { "first_seen": "2026-10-30T13:26:54Z", "native_id": "W4399708873", "source": "openalex", "url": "https://doi.org/10.1038/s41593-026-02301-4" } ], "subjects": [ { "field": "medicine", "origin": "openalex:2728|Deep Brain Stimulation and Movement Disorders", "subfield": "neurology" } ], "title": "Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks", "title_text": "Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks", "type": "peer-reviewed", "updated_at": "2026-11-04T13:21:13Z", "url": "https://research.draconitic.com/paper/48fbbpyhaxrap", "venue": "Nature Neuroscience", "versions": [] }