{
  "abstract": "Autophagy involves the rapid growth of phagophores through membrane addition. This growth is triggered by vesicles containing the Atg9A protein. However, Atg9A is not incorporated into mature autophagosomes. We now demonstrate that Dynamin-2 (Dnm2) colocalizes with the BAR domain protein endophilin B1 (EndoB1/Bif-1/SH3GLB1) and other autophagy proteins when autophagy is induced. Our data suggest that Atg9A is retrieved from phagophores via fission, with help from Dnm2. Blocking Atg9A recycling, by mutating Dnm2, using RNA interference, or applying chemical inhibitors, causes Atg9A to remain in autophagosomes and be degraded during autophagy. Overall, these findings provide new insights into the roles of Dnm2 in autophagy.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA",
    "Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Andrew Caliri"
    },
    {
      "affs": [
        0
      ],
      "name": "Alejandro Martorell-Riera"
    },
    {
      "affs": [
        0
      ],
      "name": "Panagiota Kolitsida",
      "orcid": "0000-0002-7330-1766"
    },
    {
      "affs": [
        0
      ],
      "name": "Akash Saha"
    },
    {
      "affs": [
        0
      ],
      "name": "Cinta Iriondo-Martinez"
    },
    {
      "affs": [
        0
      ],
      "name": "Samuel Itskanov",
      "orcid": "0000-0003-0705-2359"
    },
    {
      "affs": [
        1
      ],
      "name": "Janos Steffen"
    },
    {
      "affs": [
        1
      ],
      "name": "Carla M. Koehler",
      "orcid": "0000-0001-8685-2412"
    },
    {
      "affs": [
        0
      ],
      "name": "Alexander M. van der Bliek",
      "orcid": "0000-0002-6211-5765"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/48vp30btdv35c.bib",
  "cited_by": 0,
  "doi": "10.1242/bio.062632",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13714872/",
  "id": "48vp30btdv35c",
  "issns": [
    "2046-6390"
  ],
  "landing_url": "https://doi.org/10.1242/bio.062632",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2713|Autophagy in Disease and Therapy"
    ]
  ],
  "openalex": "W7135238977",
  "pdf_url": null,
  "pmcid": "PMC13714872",
  "pmid": "42779336",
  "published": "2026-10-16",
  "publisher": "Company of Biologists",
  "ris": "https://research.draconitic.com/paper/48vp30btdv35c.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:22:17Z",
      "native_id": "PMC13714872",
      "source": "pmc",
      "url": "https://doi.org/10.1242/bio.062632"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Autophagy in Disease and Therapy",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Dynamin-2 promotes Atg9A retrieval from phagophores during autophagy",
  "title_text": "Dynamin-2 promotes Atg9A retrieval from phagophores during autophagy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:17Z",
  "url": "https://research.draconitic.com/paper/48vp30btdv35c",
  "venue": "Biology Open",
  "versions": []
}