{
  "abstract": "Biomarkers of cerebral amyloid angiopathy (CAA) are critically needed. We recently identified semaphorin 3G (SEMA3G) as a novel protein selectively enriched in CAA. Here, we aimed to determine if SEMA3G was a selective marker of CAA in a large cohort of human brain tissue spanning multiple neurodegenerative diseases and three brain regions, and to determine if SEMA3G directly interacts with amyloid beta (A{beta}). Multiplexed immunofluorescence showed that SEMA3G significantly accumulated only in CAA+ blood vessels in the brain in all cases. We also showed that SEMA3G preferentially associated with A{beta}40, A{beta}pS8 and A{beta}pE3, but not A{beta}42. Thioflavin T assays and transmission electron microscopy showed that SEMA3G directly interacted with A{beta} and slowed A{beta} aggregation in vitro, and that this effect was more pronounced for A{beta}40 than A{beta}42. Together our results demonstrate that SEMA3G is a highly specific marker of CAA in the brain.",
  "abstract_shown": true,
  "affiliations": [
    "University of Sydney"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "K. Balcomb"
    },
    {
      "name": "J. Buchanan"
    },
    {
      "name": "A. Strobbe"
    },
    {
      "name": "D. Claus"
    },
    {
      "name": "A. Faustin"
    },
    {
      "name": "J. Schneider"
    },
    {
      "name": "T. Wisniewski"
    },
    {
      "name": "M. Sunde"
    },
    {
      "affs": [
        0
      ],
      "name": "E. Drummond"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/48z9btwhjy6df.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.10.750803",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750803v1.full",
  "id": "48z9btwhjy6df",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750803v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2728|Intracerebral and Subarachnoid Hemorrhage Research"
    ]
  ],
  "openalex": "W7213469440",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750803v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/48z9btwhjy6df.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:43Z",
      "native_id": "10.64898/2026.09.10.750803",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750803v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Semaphorin 3G (SEMA3G) is a highly selective marker of cerebral amyloid angiopathy",
  "title_text": "Semaphorin 3G (SEMA3G) is a highly selective marker of cerebral amyloid angiopathy",
  "type": "preprint",
  "updated_at": "2026-10-30T12:22:43Z",
  "url": "https://research.draconitic.com/paper/48z9btwhjy6df",
  "venue": "bioRxiv",
  "versions": []
}