{
  "abstract": "Objective: To verify the clinical performance of the Mindray MN2880 system for simultaneous detection of SARS‐CoV‐2, influenza A virus (IAV), influenza B virus (IBV), and respiratory syncytial virus (RSV) nucleic acids.\n\nMethods: According to the CNAS‐GL039:2019 and CNAS‐GL037:2019 requirements for molecular diagnostic verification, we comprehensively evaluated the Mindray MN2880 multiplex respiratory virus assay across seven critical performance parameters: clinical concordance, limit of detection (LoD), repeatability, precision, cross‐reactivity/interference resistance, daily QC, and contamination control.\n\nResults: The Mindray MN2880 system demonstrated high diagnostic concordance with the reference method, with total percent agreements of 99.51% (95% CI: 99.00%–99.76%) for SARS‐CoV‐2, 99.93% (95% CI: 99.60%–99.99%) for IAV, and 100% for both IBV and RSV, and achieved clinically verified limits of detection (LoD: SARS‐CoV‐2 at 100 copies/mL, IAV/IBV/RSV at 200 copies/mL). Analytical precision was confirmed through 100% detection across negative/low/medium/high concentration panels with ≤ 3% CV for repeatability (Ct values) and ≤ 5% CV for inter‐run precision. The assay exhibited 100% specificity against 6 clinically relevant pathogens, including Human Rhinovirus, parainfluenza virus, adenovirus, Mycoplasma pneumoniae , Haemophilus influenzae , and Staphylococcus aureus , with no observed cross‐reactivity. Moreover, the MN2880 system demonstrated robust interference resistance (100% detection of weakly‐positive samples spiked with seven interferents), stable daily QC performance (100% valid controls across 115 consecutive runs), and 100% contamination prevention.\n\nConclusion: The MN2880 system satisfies key analytical benchmarks required for diagnostic use in respiratory virus multiplex testing, with performance verified against CNAS‐GL039:2019 and CNAS‐GL037:2019 standards.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medical Laboratory Chaozhou People's Hospital Affiliated to Shantou University Medical College Chaozhou Guangdong China",
    "Department of Laboratory Medicine People's Hospital of Boluo County Huizhou Guangdong China",
    "Department of Laboratory Medicine The First Affiliated Hospital, Sun Yat‐Sen University Guangzhou Guangdong China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jinliang Chen",
      "orcid": "0009-0008-5451-8928"
    },
    {
      "affs": [
        1
      ],
      "name": "Lianying Zeng"
    },
    {
      "affs": [
        2
      ],
      "name": "Hao Huang",
      "orcid": "0000-0002-2029-2667"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Peisong Chen",
      "orcid": "0000-0003-0640-3663"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/498yfawn2espg.bib",
  "cited_by": 0,
  "doi": "10.1002/jcla.70390",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696938/",
  "id": "498yfawn2espg",
  "issns": [
    "0887-8013",
    "1098-2825"
  ],
  "landing_url": "https://doi.org/10.1002/jcla.70390",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2725|SARS-CoV-2 detection and testing"
    ]
  ],
  "openalex": "W7223685506",
  "pdf_url": "https://europepmc.org/articles/PMC13696938?pdf=render",
  "pmcid": "PMC13696938",
  "pmid": "42928602",
  "published": "2026-10-25",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/498yfawn2espg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:12Z",
      "native_id": "PMC13696938",
      "source": "pmc",
      "url": "https://doi.org/10.1002/jcla.70390"
    },
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42928602",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42928602"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|SARS-CoV-2 detection and testing",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Comprehensive Performance Verification of the Mindray MN2880 System in Detecting Respiratory Virus Nucleic Acids",
  "title_text": "Comprehensive Performance Verification of the Mindray MN2880 System in Detecting Respiratory Virus Nucleic Acids",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:34:11Z",
  "url": "https://research.draconitic.com/paper/498yfawn2espg",
  "venue": "Journal of Clinical Laboratory Analysis",
  "versions": []
}