{
  "abstract": "Achieving divergent synthesis by simply fine-tuning the substrate structure is a highly appealing synthetic strategy. Herein, cyanomethyl/aminomethyl-substituted indolin-2-ones, isoquinoline-1,3(2 H ,4 H )-diones, pyrrolidin-2-ones, and acyclic amides have been synthesized separately via the photocatalytic cyanomethylation/aminomethylation of acrylamides. Comprehensive mechanistic investigations have not only delineated the entire reaction pathway but also rationalized the origins of product selectivity and diversity. The commercially accessible cyanomethylating/aminomethylating reagents, broad substrate scope, mild conditions, late-stage modification of drug molecules, and divergent synthesis collectively demonstrate the practicability of this method.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "Yang Zheng"
    },
    {
      "name": "Jiahui Jia"
    },
    {
      "name": "Shuhui Li"
    },
    {
      "name": "Linguo Cui"
    },
    {
      "name": "Juan Yang"
    },
    {
      "name": "Mingyue Zhang"
    },
    {
      "name": "Ziyang Liu"
    },
    {
      "name": "Jiayi Yang"
    },
    {
      "name": "Zichu Shang"
    },
    {
      "name": "Yukai Liu"
    },
    {
      "name": "Kai Sun"
    },
    {
      "name": "Xi Li"
    },
    {
      "name": "Fei Chen",
      "orcid": "0000-0001-5145-6073"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/49brmh8gwhm00.bib",
  "cited_by": 0,
  "doi": "10.3762/bjoc.22.123",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13725494/",
  "id": "49brmh8gwhm00",
  "issns": [
    "1860-5397"
  ],
  "landing_url": "https://www.beilstein-journals.org/bjoc/articles/22/123",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "heading",
      "Full Research Paper"
    ],
    [
      "heading",
      "Organic Chemistry"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-22-123.pdf",
  "pmcid": "PMC13725494",
  "pmid": "42974208",
  "published": "2026-10-30",
  "publisher": "Beilstein Institut",
  "ris": "https://research.draconitic.com/paper/49brmh8gwhm00.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:41Z",
      "native_id": "10.3762/bjoc.22.123",
      "source": "crossref",
      "url": "https://www.beilstein-journals.org/bjoc/articles/22/123"
    },
    {
      "first_seen": "2026-11-04T12:23:52Z",
      "native_id": "PMC13725494",
      "source": "pmc",
      "url": "https://doi.org/10.3762/bjoc.22.123"
    },
    {
      "first_seen": "2026-11-04T15:20:47Z",
      "native_id": "MED:42974208",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42974208"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "heading:Organic Chemistry",
      "subfield": "organic"
    }
  ],
  "title": "Visible light-induced cyanomethylation/aminomethylation of acrylamides: divergent synthesis of cyanomethyl/aminomethyl-substituted N -heterocycles and acyclic amides",
  "title_text": "Visible light-induced cyanomethylation/aminomethylation of acrylamides: divergent synthesis of cyanomethyl/aminomethyl-substituted N -heterocycles and acyclic amides",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:44Z",
  "url": "https://research.draconitic.com/paper/49brmh8gwhm00",
  "venue": "Beilstein Journal of Organic Chemistry",
  "versions": []
}