{
  "abstract": "BACKGROUND: Changes in mitral valve (MV) morphology during MV transcatheter edge-to-edge repair (MV-TEER) are associated with short-term reduction of mitral regurgitation (MR). However, whether these changes are associated with prognosis remains unclear. Using 3-dimensional transesophageal echocardiography, this study evaluated the impact of MV morphological parameters on the mid-term prognosis of patients with functional MR (FMR). METHODS AND RESULTS: We analyzed 99 patients with FMR who were treated with MV-TEER. The primary endpoint was a composite of all-cause mortality and hospitalization due to heart failure. Patients were divided into 2 groups based on the post-procedural sphericity index of the mitral valve (SI-MV), which is the ratio of the vertical to horizontal MV diameter. Using receiver operating characteristic curve (ROC) analysis for the primary endpoint, the SI-MV cut-off value was determined to be 0.86. The incidence of the primary endpoint was significantly (log-rank P=0.013) higher among patients with a post-procedural SI-MV >0.86 (circular MV morphology) than among those with post-procedural SI-MV ≤0.86 (elliptical MV morphology). Post-procedural SI-MV >0.86 was an independent determinant of the primary endpoint in multivariate analysis (hazard ratio 2.35; 95% confidence interval 1.25-4.42; P=0.0077). CONCLUSIONS: A larger post-procedural SI-MV is associated with increased mid-term adverse clinical events after MV-TEER in patients with FMR.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "name": "Takanori Kawamoto"
    },
    {
      "name": "Chihiro Koyanagi"
    },
    {
      "name": "Yuichiro Minami"
    },
    {
      "name": "Yukako Tanaka"
    },
    {
      "name": "Masafumi Yoshikawa"
    },
    {
      "name": "Eiji Shibahashi"
    },
    {
      "name": "Kaoru Haruki"
    },
    {
      "name": "Risako Nakao"
    },
    {
      "name": "Yusuke Inagaki"
    },
    {
      "name": "Hisao Otsuki"
    },
    {
      "name": "Tomohito Kogure"
    },
    {
      "name": "Satoru Domoto"
    },
    {
      "name": "Kyomi Ashihara"
    },
    {
      "name": "Hiroshi Niinami"
    },
    {
      "name": "Junichi Yamaguchi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/49h285cf6gwnv.bib",
  "cited_by": 1,
  "doi": "10.1253/circj.cj-25-0457",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/circj/90/9/90_CJ-25-0457/_article",
  "id": "49h285cf6gwnv",
  "issns": [
    "1347-4820",
    "1346-9843"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/circj/90/9/90_CJ-25-0457/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/cardiovascular"
    ],
    [
      "openalex",
      "2705|Cardiac Valve Diseases and Treatments"
    ]
  ],
  "openalex": "W4415289160",
  "pdf_url": "https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-25-0457/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/49h285cf6gwnv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.1253/circj.cj-25-0457",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/circj/90/9/90_CJ-25-0457/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiac Valve Diseases and Treatments",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Prognostic Impact of Mitral Valve Sphericity Index After Mitral Valve Transcatheter Edge-to-Edge Repair in Functional Mitral Regurgitation",
  "title_text": "Prognostic Impact of Mitral Valve Sphericity Index After Mitral Valve Transcatheter Edge-to-Edge Repair in Functional Mitral Regurgitation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/49h285cf6gwnv",
  "venue": "Circulation Journal",
  "versions": []
}