{
  "abstract": "Well-defined (TTP)TiII (TTP = 5,10,15,20-tetratolylporphyrin) complexes have been shown to promote stoichiometric deoxygenation of organic molecules, such as sulfoxides and epoxides, forming a stable (TTP)TiIV=O product. Here, we explore strategies to promote catalytic deoxygenation reactivity by regenerating (TTP)TiII through chemical or electrochemical reduction. A survey of Lewis acids revealed the effectiveness of B(OPh)3 in promoting activation and loss of the Ti-oxo group, enabling TiII-mediated reductive oxygen-atom transfer (OAT) of diphenyl sulfoxide. Cyclic voltammetry, coulometry, EPR spectroscopy, and X-ray crystallography have been used to probe and characterize TiIII and TiII species from the electroreductive deoxygenation of the TiIV=O complex. The data implicate a Lewis-acid-coupled electron-transfer deoxygenation pathway for TiIV=O turnover. These fundamental studies are complemented by electrochemical reactions demonstrating catalytic reductive oxygen-atom transfer from sulfoxides, pyridine N-oxides, and epoxides.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin53706, United States."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ruohan Deng"
    },
    {
      "affs": [
        0
      ],
      "name": "Tianxiao Jiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Haoran Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Ilia A Guzei",
      "orcid": "0000-0003-1976-7386"
    },
    {
      "affs": [
        0
      ],
      "name": "Leah C Garman",
      "orcid": "0000-0002-3445-652X"
    },
    {
      "affs": [
        0
      ],
      "name": "Xianyuan Zhao",
      "orcid": "0000-0001-7926-6562"
    },
    {
      "affs": [
        0
      ],
      "name": "Yang Yang",
      "orcid": "0000-0001-8572-5155"
    },
    {
      "affs": [
        0
      ],
      "name": "Shannon S Stahl",
      "orcid": "0000-0002-9000-7665"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/49m1myxzfew5g.bib",
  "cited_by": 0,
  "doi": "10.1021/jacs.6c11967",
  "fulltext_url": "https://europepmc.org/articles/PMC13596083",
  "id": "49m1myxzfew5g",
  "issns": [
    "0002-7863",
    "1520-5126"
  ],
  "landing_url": "https://europepmc.org/article/MED/42915524",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1604|Metal-Catalyzed Oxygenation Mechanisms"
    ]
  ],
  "openalex": "W7207540898",
  "pdf_url": "https://europepmc.org/articles/PMC13596083?pdf=render",
  "pmcid": "PMC13596083",
  "pmid": "42915524",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/49m1myxzfew5g.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:02Z",
      "native_id": "MED:42915524",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42915524"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1604|Metal-Catalyzed Oxygenation Mechanisms",
      "subfield": "inorganic"
    }
  ],
  "title": "Electrochemical Deoxygenation of a TiIV-Oxo Complex to Enable Catalytic Reductive Oxygen-Atom Transfer from Organic Molecules.",
  "title_text": "Electrochemical Deoxygenation of a TiIV-Oxo Complex to Enable Catalytic Reductive Oxygen-Atom Transfer from Organic Molecules.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:02Z",
  "url": "https://research.draconitic.com/paper/49m1myxzfew5g",
  "venue": "Journal of the American Chemical Society",
  "versions": []
}