{
  "abstract": "The direct arylation of juglone enables concise access to WS-5995A and the related natural product WS-5995C, providing an entry to the WS-5995 family. The method affords access to lactam analogs via either C-2 or C-3 arylation, enabling the variation of the phenolic hydroxyl position. Cytotoxicity studies reveal a pronounced effect of the phenolic hydroxyl group positioning on biological activity, with the C-3-derived lactam showing enhanced potency. Further demethylation of WS-5995A increases activity, suggesting an important role of a free phenolic hydroxyl group.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Yusuke Akagi"
    },
    {
      "name": "Yoshimi Shimizu"
    },
    {
      "name": "Erika Iwasaki"
    },
    {
      "name": "Yuichiro Taira"
    },
    {
      "name": "Toshiya Komatsu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/49qn3gejnr7pz.bib",
  "cited_by": 0,
  "doi": "10.1248/cpb.c26-00475",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/cpb/74/10/74_c26-00475/_article",
  "id": "49qn3gejnr7pz",
  "issns": [
    "1347-5223",
    "0009-2363"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/cpb/74/10/74_c26-00475/_article",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "chemistry/medicinal"
    ],
    [
      "openalex",
      "1605|Catalytic C–H Functionalization Methods"
    ]
  ],
  "openalex": "W7223665849",
  "pdf_url": "https://www.jstage.jst.go.jp/article/cpb/74/10/74_c26-00475/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-27",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/49qn3gejnr7pz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:34Z",
      "native_id": "10.1248/cpb.c26-00475",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/cpb/74/10/74_c26-00475/_article"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Catalytic C–H Functionalization Methods",
      "subfield": "organic"
    }
  ],
  "title": "Direct Arylation of Juglone Enables Divergent Access to WS-5995 Analogs",
  "title_text": "Direct Arylation of Juglone Enables Divergent Access to WS-5995 Analogs",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:34Z",
  "url": "https://research.draconitic.com/paper/49qn3gejnr7pz",
  "venue": "Chemical and Pharmaceutical Bulletin",
  "versions": []
}