{
  "abstract": "There are three classes of neutral 6-membered reactive species, namely didehydrobenzene (benzyne (1)), dihydrobenzenes (cyclohexyne (2) and 1,2-cyclohexadiene (3)), and benzene isomers (cyclohexen-3-yne (4), 1,2,3-cyclohexatriene (5), and 1,2,4-cyclohexatriene (6)). Although intermediates 1-3 have found broad synthetic applications, the benzene isomers 4-6 received only sporadic attention. To further explore their synthetic utility and, more importantly, to uncover their potential in preparing polysubstituted 1,3-cyclohexadienes, we successfully incorporate cyclohexen-3-yne and 1,2,3-cyclohexatriene into several cascade transformations, such as 1,3-diamination, nucleophilic addition-ene reaction, and nucleophilic addition-[4+2] cycloaddition reaction. Additionally, a 1,5-sulfonyl group migration could occur to deliver a sulfone to the C4-position of the 1,3-cyclohexadiene framework. As a result, a series of 1,2-disubstituted, 1,2,3-trisubstituted, 1,2,4-trisubstituted, and 1,2,3,4-tetrasubstituted 1,3-cyclohexadienes bearing polycyclic ring systems can be efficiently prepared. This study offers a distinctive perspective on these aspects of reactive benzene isomers.",
  "abstract_shown": true,
  "affiliations": [
    "School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, PR China.",
    "School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, PR China. lianggui-li@foxmail.com.",
    "School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, PR China. y.li@cqu.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Wenhao Yin"
    },
    {
      "affs": [
        0
      ],
      "name": "Ranran Xia"
    },
    {
      "affs": [
        0
      ],
      "name": "Li Xu"
    },
    {
      "affs": [
        1
      ],
      "name": "Lianggui Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Yang Li",
      "orcid": "0000-0002-0090-2894"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4a4c469wg6khf.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77981-4",
  "fulltext_url": "https://europepmc.org/articles/PMC13687091",
  "id": "4a4c469wg6khf",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://europepmc.org/article/MED/42907463",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Cyclization and Aryne Chemistry"
    ]
  ],
  "openalex": "W7213882333",
  "pdf_url": "https://europepmc.org/articles/PMC13687091?pdf=render",
  "pmcid": "PMC13687091",
  "pmid": "42907463",
  "published": "2026-09-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4a4c469wg6khf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:57Z",
      "native_id": "MED:42907463",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42907463"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Cyclization and Aryne Chemistry",
      "subfield": "organic"
    }
  ],
  "title": "Tandem cyclohexen-3-yne and 1,2,3-cyclohexatriene reactions.",
  "title_text": "Tandem cyclohexen-3-yne and 1,2,3-cyclohexatriene reactions.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:57Z",
  "url": "https://research.draconitic.com/paper/4a4c469wg6khf",
  "venue": "Nature communications",
  "versions": []
}