{
  "abstract": "Objective\n\nEndograft explantation is associated with high morbidity and mortality, driven in part by uncontrolled shear-mediated aortic injury. In this study, we evaluated whether a mechanism-based explantation device could reduce this injury and improve the procedural performance.Methods\n\nIn a controlled simulation using a multilayered three-dimensional printed aortic model, 25 vascular trainees and surgeons performed endograft explantation using both a conventional syringe technique and a novel device (EndoEx). The outcomes included quantitative intimal injury, procedure time, and validated usability metrics.Results\n\nThe EndoEx device reduced intimal injury by approximately 90% compared with the syringe technique (0.94% vs 9.56%; P < .001), representing near-elimination of shear-mediated disruption. The procedure time was moderately longer (+32 seconds; P < .05). EndoEx demonstrated superior usability across all domains, including ease of use, safety perception, and overall cognitive load (P < .05).Conclusions\n\nIn this controlled simulation, a mechanism-based explantation strategy (EndoEx) markedly reduced shear-mediated aortic injury while improving operator control. These findings support further in vivo evaluation and establish a mechanistic foundation for a device-based approach to endovascular aneurysm repair explantation that warrants clinical validation.",
  "abstract_shown": true,
  "affiliations": [
    "Texas A&M School of Engineering Medicine, Houston, TX.",
    "Department of Cardiovascular Surgery, Houston Methodist Hospital, Houston, TX."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zain Moin"
    },
    {
      "affs": [
        0
      ],
      "name": "Alayne Morrel"
    },
    {
      "affs": [
        1
      ],
      "name": "Maham Rahimi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4a5s08xkm5tt8.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jvscit.2026.102489",
  "fulltext_url": "https://europepmc.org/articles/PMC13682454",
  "id": "4a5s08xkm5tt8",
  "issns": [
    "2468-4287"
  ],
  "landing_url": "https://europepmc.org/article/MED/42904182",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Aortic aneurysm repair treatments"
    ]
  ],
  "openalex": "W7207534280",
  "pdf_url": "https://europepmc.org/articles/PMC13682454?pdf=render",
  "pmcid": "PMC13682454",
  "pmid": "42904182",
  "published": "2026-09-03",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4a5s08xkm5tt8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:57Z",
      "native_id": "MED:42904182",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42904182"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:2746|Infectious Aortic and Vascular Conditions",
      "subfield": "surgery"
    }
  ],
  "title": "Mechanism-guided endograft explantation eliminates shear-mediated aortic injury in a controlled simulation study.",
  "title_text": "Mechanism-guided endograft explantation eliminates shear-mediated aortic injury in a controlled simulation study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:57Z",
  "url": "https://research.draconitic.com/paper/4a5s08xkm5tt8",
  "venue": "Journal of vascular surgery cases and innovative techniques",
  "versions": []
}