{
  "abstract": "BackgroundRefractory and macrolide-resistant Mycoplasma pneumoniae pneumonia (MPP) has emerged as a major challenge in pediatric respiratory medicine, amplified by the post-2023 resurgence. However, a systematic overview of the research landscape specific to treatment-refractory and drug-resistant disease in children remains lacking.\n\nMethodsResearch articles and reviews on pediatric refractory or macrolide-resistant MPP published between 2000 and 2025 were retrieved from OpenAlex using Boolean searches. After screening, 2,286 records were quantitatively analyzed for annual output, contributing countries/institutions, thematic clusters, and citation-burst dynamics using Python.\n\nResultsAnnual publications grew exponentially, with a pronounced surge after 2023 (n=378 in 2025). China produced the highest volume (45.1%) but recorded fewer citations per publication than the US, Japan, and Canada. The literature resolved into four clusters: macrolide resistance/molecular basis, epidemiology, etiology/co-infection, and refractory disease management. Burst analysis showed an evolution from earlier fronts like 23S rRNA mutations and azithromycin to recent emerging trends like pandemic-related co-circulation, genotype surveillance, and co-infection.\n\nConclusionsResearch on pediatric refractory and resistant MPP is expanding rapidly, shifting in emphasis from etiologic descriptions toward resistance mechanisms and clinical management. Standardizing the treatment of macrolide-unresponsive disease and post-pandemic epidemiological surveillance represent the principal directions for future work.",
  "abstract_shown": true,
  "affiliations": [
    "Beijing Children's Hospital, Capital Medical University"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "D. Li"
    },
    {
      "name": "H. Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "C. Shen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4a8r52bekcd5k.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.08.25.26361371",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.08.25.26361371v1.full",
  "id": "4a8r52bekcd5k",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.08.25.26361371v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "infectious diseases"
    ],
    [
      "openalex",
      "2404|Microbial infections and disease research"
    ]
  ],
  "openalex": "W7204764191",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.08.25.26361371v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4a8r52bekcd5k.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:21Z",
      "native_id": "10.64898/2026.08.25.26361371",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.08.25.26361371v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:infectious diseases",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Global research trends and emerging fronts in refractory and macrolide-resistant Mycoplasma pneumoniae pneumonia in children: a bibliometric analysis (2000 2025)",
  "title_text": "Global research trends and emerging fronts in refractory and macrolide-resistant Mycoplasma pneumoniae pneumonia in children: a bibliometric analysis (2000 2025)",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:21Z",
  "url": "https://research.draconitic.com/paper/4a8r52bekcd5k",
  "venue": "medRxiv",
  "versions": []
}