{
  "abstract": "Background/Objectives: Prognostic PET biomarkers in glioblastoma remain mostly as a single tracer and poorly characterized at recurrence. We investigated whether paired [18F]FDOPA/[18F]FDG PET captures complementary metabolic information associated with survival in IDH-wildtype glioblastoma. Methods: Sixty-five consecutive patients underwent paired [18F]FDOPA/[18F]FDG PET/MR at baseline and/or recurrence. Survival was analyzed from baseline PET/MR (OS1, n = 36) and recurrence PET/MR (OS2, n = 55); longitudinal analyses used the paired subgroup (n = 26). FDOPA and FDG tumor masks were independently segmented within a FLAIR-derived tumor box, and metrics were extracted from tracer-specific masks, their intersection, and their union. Metrics significant in Kaplan–Meier or univariable Cox analyses were tested in adjusted Cox models. Benjamini–Hochberg false discovery rate correction was used as a sensitivity analysis for the continuous Cox screening tests. Results: In exploratory screening, prognostic associations were sparse at baseline and more prominent at recurrence. At OS2, three metrics remained independently associated with survival after adjustment: the FDOPA/FDG union-domain SUVmeanunion ratio (HR, 1.50; p = 0.0168), MTVinter (HR, 1.63; p = 0.0154), and MTVDOPA (HR, 1.58; p = 0.0191). The SUVmeanunion ratio and MTVDOPA showed limited correlation, suggesting complementary information. Their integration into IR-MTVDOPA, defined as FDOPA/FDG SUVmeanunion ratio × log(MTVDOPA), showed higher apparent OS2 discrimination (HR, 1.73; log-rank p = 0.0001; C-index, 0.730; bootstrap .632-corrected C-index, 0.684; 12-month AUC, 0.863). Conclusions: In this exploratory single-center cohort, paired [18F]FDOPA/[18F]FDG PET showed prognostic associations at recurrence. Inter-tracer intensity balance and metabolic tumor burden provided partially complementary survival information, and their exploratory integration showed higher apparent discrimination. External validation is required before clinical implementation.",
  "abstract_shown": true,
  "affiliations": [
    "Service de Neurochirurgie, Hôpitaux Universitaires de Strasbourg (HUS), 67200 Strasbourg, France",
    "ICube, Université de Strasbourg/CNRS (UMR 7357), 67085 Strasbourg, France",
    "Service de Médecine Nucléaire et d’Imagerie Moléculaire, Institut Strauss, 67200 Strasbourg, France"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Julien Todeschi"
    },
    {
      "affs": [
        2
      ],
      "name": "Julien Salvadori"
    },
    {
      "affs": [
        2
      ],
      "name": "Oreste Allegrini"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hélène Cebula"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Caroline Bund"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Izzie-Jacques Namer"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4aejwyykz6vw4.bib",
  "cited_by": 0,
  "doi": "10.3390/cancers18203333",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702550/?tool=EBI",
  "id": "4aejwyykz6vw4",
  "issns": [
    "2072-6694"
  ],
  "landing_url": "https://www.mdpi.com/2072-6694/18/20/3333",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2716|Glioma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7222316737",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702550/pdf/?tool=EBI",
  "pmcid": "PMC13702550",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/4aejwyykz6vw4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:58Z",
      "native_id": "10.3390/cancers18203333",
      "source": "crossref",
      "url": "https://www.mdpi.com/2072-6694/18/20/3333"
    },
    {
      "first_seen": "2026-10-30T12:21:45Z",
      "native_id": "PMC:PMC13702550",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13702550"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Glioma Diagnosis and Treatment",
      "subfield": "human-genetics"
    }
  ],
  "title": "Paired [18F]FDOPA and [18F]FDG PET Shows Complementary Prognostic Associations at Recurrence in IDH-Wildtype Glioblastoma",
  "title_text": "Paired [18F]FDOPA and [18F]FDG PET Shows Complementary Prognostic Associations at Recurrence in IDH-Wildtype Glioblastoma",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:45Z",
  "url": "https://research.draconitic.com/paper/4aejwyykz6vw4",
  "venue": "Cancers",
  "versions": []
}