{
  "abstract": "The consequences of oligodendrocyte involvement in Alzheimer’s disease are poorly understood. Could a key role of gray-matter oligodendrocytes—activity-dependent adaptive myelination to sustain changes in activity—be perturbed, leading to cognitive loss?\n\nThe consequences of oligodendrocyte involvement in Alzheimer’s disease are poorly understood. This Perspective suggests that activity-dependent adaptive myelination, a key role of grey-matter oligodendrocytes, could be perturbed, leading to cognitive loss.",
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  "affiliations": [
    "Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, United Kingdom"
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  "article_type": "Perspective",
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  "author_total": 1,
  "authors": [
    {
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      "name": "Charles ffrench-Constant"
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  "doi": "10.1371/journal.pbio.3004033",
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  "native_subjects": [
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      "/Medicine and health sciences/Neurology/Dementia/Alzheimer's disease"
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      "/Medicine and health sciences/Neurology/Neurodegenerative diseases/Alzheimer's disease"
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  "pmcid": null,
  "pmid": null,
  "published": "2026-10-12",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/4anv1nnx6a3x5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:30Z",
      "native_id": "10.1371/journal.pbio.3004033",
      "source": "plos",
      "url": "https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3004033"
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  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "plos:cell biology",
      "subfield": "cell-biology"
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    {
      "field": "biology",
      "origin": "plos:neuroscience",
      "subfield": "neuroscience"
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    {
      "field": "medicine",
      "origin": "plos:anatomy",
      "subfield": "physiology"
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  "title": "Does perturbed adaptive myelination contribute to cognitive dysfunction in Alzheimer’s disease?",
  "title_text": "Does perturbed adaptive myelination contribute to cognitive dysfunction in Alzheimer’s disease?",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:30Z",
  "url": "https://research.draconitic.com/paper/4anv1nnx6a3x5",
  "venue": "PLOS Biology",
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}