{
  "abstract": "Halogen bonding (XB) is a recognition motif of increasing importance but it remains underused in solution. Embedding a single XB motif within a molecular capsule improves both its stability and interaction strength by finely tuning inward position and orientation. In this context, a new Covalent Organic Cage (COC) was prepared sequestering a polarized P‐Cl bond. This hemicryptophane carrying a haloazaphosphatrane moiety was found to bind dimethyl methylphosphonate (DMMP), a Sarin surrogate, by halogen bonding with atomic precision. Indeed, the same cage having the chlorine atom substituted by a hydrogen atom showed no detectable recognition. Such level of discrimination definitely establishes halogen bonding COC as a new generation of efficient receptors for molecular recognition.",
  "abstract_shown": true,
  "affiliations": [
    "Aix Marseille Univ, CNRS, Centrale Med, iSm2 Marseille France",
    "State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences Fuzhou China",
    "IPCM, UMR 8232 Sorbonne Univ, CNRS Paris France",
    "LIMA, UMR 7042 Univ Strasbourg, Univ Haute Alsace, CNRS Strasbourg France",
    "LCH UMR 5182 CNRS, ENS de Lyon, Lyon 1 Université Lyon France",
    "Aix Marseille Univ, CNRS, ICR Marseille France"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Pierre‐Antoine Dupin",
      "orcid": "0009-0000-9081-5470"
    },
    {
      "affs": [
        1
      ],
      "name": "Jian Yang",
      "orcid": "0009-0000-6770-8685"
    },
    {
      "affs": [
        0
      ],
      "name": "Elise Antonetti"
    },
    {
      "affs": [
        2
      ],
      "name": "Bastien Chatelet",
      "orcid": "0000-0001-7456-4704"
    },
    {
      "affs": [
        3
      ],
      "name": "Xavier Bugaut",
      "orcid": "0000-0002-8424-0129"
    },
    {
      "affs": [
        4
      ],
      "name": "Jean‐Pierre Dutasta"
    },
    {
      "affs": [
        0
      ],
      "name": "Paola Nava",
      "orcid": "0000-0002-8909-8002"
    },
    {
      "affs": [
        5
      ],
      "name": "Anne‐Doriane Manick"
    },
    {
      "affs": [
        0
      ],
      "name": "David Bardelang",
      "orcid": "0000-0002-0318-5958"
    },
    {
      "affs": [
        0
      ],
      "name": "Alexandre Martinez",
      "orcid": "0000-0002-6745-5734"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4bb0vy56dj1xm.bib",
  "cited_by": 0,
  "doi": "10.1002/anie.5640364",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13725614/",
  "id": "4bb0vy56dj1xm",
  "issns": [
    "1433-7851",
    "1521-3773"
  ],
  "landing_url": "https://doi.org/10.1002/anie.5640364",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Communication"
    ],
    [
      "openalex",
      "1606|Crystallography and molecular interactions"
    ]
  ],
  "openalex": "W7214549537",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.5640364",
  "pmcid": "PMC13725614",
  "pmid": "42801472",
  "published": "2026-09-27",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4bb0vy56dj1xm.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:57Z",
      "native_id": "PMC13725614",
      "source": "pmc",
      "url": "https://doi.org/10.1002/anie.5640364"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1606|Crystallography and molecular interactions",
      "subfield": "physical"
    }
  ],
  "title": "Molecular Recognition by Halogen Bonding With Atomic Precision in a Covalent Organic Cage",
  "title_text": "Molecular Recognition by Halogen Bonding With Atomic Precision in a Covalent Organic Cage",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:48Z",
  "url": "https://research.draconitic.com/paper/4bb0vy56dj1xm",
  "venue": "Angewandte Chemie (International Ed. in English)",
  "versions": []
}