{
  "abstract": "BACKGROUND AND OBJECTIVES:: Tuberculosis remains a major global health burden, with central nervous system (CNS) involvement accounting for 1% to 10% of cases. Intraventricular tuberculoma is a distinct, poorly documented entity, separate from tuberculous meningitis with hydrocephalus. This systematic review assessed the epidemiology, diagnosis, management, and outcomes of CNS intraventricular tuberculoma.\n\nMETHODS:: PubMed and Scopus were searched per Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines for studies on CNS intraventricular tuberculoma (PROSPERO registration number CRD420251017978). Pooled data were summarized using measures of central tendency and dispersion.\n\nRESULTS:: Of 841 records identified, 18 studies (17 case reports, 1 retrospective series) encompassing 30 patients were included. Patients were predominantly male (53.3%), with a median age of 24 years [IQR 11.5-31.8]. The median symptom duration before admission was 3 months [IQR 2-4]; headache (76.7%) and fever (66.7%) were the most common presenting symptoms. MRI was performed in 73.3% and computed tomography in 46.7% of cases. Hydrocephalus was present in 53.3% at diagnosis, and the tuberculoma was most often located in the lateral ventricle (46.7%). Antituberculous therapy alone was used in 56.7% of patients, while 43.3% received combined medical-surgical treatment; among the 13 patients treated surgically, microsurgical resection achieved gross total removal in 9 (69.2%). The median follow-up was 15.5 months [IQR 7.5-26.3], with favorable outcomes in 76.7% and mortality of 3.3%.\n\nCONCLUSION:: Intraventricular tuberculoma is a rare, distinct manifestation of CNS tuberculosis strongly associated with hydrocephalus. Prompt recognition and individualized medical-surgical management are associated with favorable outcomes, although evidence remains limited to case-level reports, warranting confirmation through prospective, multicenter studies.",
  "abstract_shown": true,
  "affiliations": [
    "Research Department of SAFNA, Cotonou, Benin",
    "Department of Neurosurgery, Teaching Hospital of Fann, Cheikh Anta Diop University, Dakar, Senegal",
    "Department of Neurosurgery, Military and Teaching Hospital of Parakou, Parakou, Benin",
    "Department of Neurosurgery, Teaching Hospital of Bouaké, Bouaké, Ivory Coast",
    "Department of Neurosurgery, Sylvanus Olympio Teaching Hospital, Lomé, Togo",
    "Laboratory of Human Anatomy, Faculty of Medicine, Félix Houphouët-Boigny University, Abidjan, Ivory Coast",
    "Department of Neurosurgery, Teaching Hospital of Yopougon, Abidjan, Ivory Coast",
    "Department of Neurosurgery, CHU CAEN Normandie, Caen, France",
    "Imaging Brain and Neuropsychiatry iBraiN U1253, INSERM, Université De Tours, Tours, France",
    "Department of Neurosurgery, Université De Tours, Tours, France"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Férol Baudelaire Babatundé Gbenou",
      "orcid": "0000-0002-9366-8207"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Yao Christian Hugues Dokponou",
      "orcid": "0000-0002-5956-2070"
    },
    {
      "affs": [
        0,
        3,
        4
      ],
      "name": "Dzidoula Late Lawson",
      "orcid": "0000-0001-9751-1031"
    },
    {
      "affs": [
        0
      ],
      "name": "Nicaise Kpegnon Agada",
      "orcid": "0000-0001-6664-7438"
    },
    {
      "affs": [
        0
      ],
      "name": "Omar Boladji Adebayo Badirou",
      "orcid": "0000-0003-2607-1539"
    },
    {
      "affs": [
        0,
        5,
        6
      ],
      "name": "Raïssa Diaby",
      "orcid": "0000-0003-2403-4267"
    },
    {
      "affs": [
        0,
        7,
        8,
        9
      ],
      "name": "Nourou Dine Adeniran Bankole",
      "orcid": "0000-0002-4277-9767"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4bgavm0kwxx92.bib",
  "cited_by": 0,
  "doi": "10.1227/neuprac.0000000000000320",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13734563/",
  "id": "4bgavm0kwxx92",
  "issns": [
    "2834-4383"
  ],
  "landing_url": "https://doi.org/10.1227/neuprac.0000000000000320",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "General Neurosurgery"
    ],
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2746|Infectious Diseases and Tuberculosis"
    ]
  ],
  "openalex": "W7225323297",
  "pdf_url": null,
  "pmcid": "PMC13734563",
  "pmid": "42985649",
  "published": "2026-11-05",
  "publisher": "Wolters Kluwer Health",
  "ris": "https://research.draconitic.com/paper/4bgavm0kwxx92.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:24:00Z",
      "native_id": "PMC13734563",
      "source": "pmc",
      "url": "https://doi.org/10.1227/neuprac.0000000000000320"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Infectious Diseases and Tuberculosis",
      "subfield": "surgery"
    }
  ],
  "title": "Intraventricular Tuberculoma of the Central Nervous System: A Systematic Review of Clinical Presentation, Management, and Outcome",
  "title_text": "Intraventricular Tuberculoma of the Central Nervous System: A Systematic Review of Clinical Presentation, Management, and Outcome",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:24:00Z",
  "url": "https://research.draconitic.com/paper/4bgavm0kwxx92",
  "venue": "Neurosurgery Practice",
  "versions": []
}