{
  "abstract": "Enantioselective construction of unnatural α-amino acids is highly desirable due to their widespread applications across biochemistry, medicinal industry and materials science. Herein, we report a straightforward and efficient method for the assembly of structurally diverse enantioenriched α-amino acid derivatives from readily accessible enamides and N,N-dimethylformamide (DMF) by merging nickel hydride catalysis and hydrogen atom transfer (HAT). The protocol affords good yields and high enantioselectivities of products which easily can be converted into unprotected unnatural α-amino acids and other valuable chiral building blocks. Notably, the enantiopurity of the products can be further enhanced by normal flash chromatography on silica gel, providing a practical platform for enantiopurification of both oily and solid products. This radical cross-coupling reaction proceeds under mild conditions, tolerates a broad range of functional groups and is amenable to the construction of enantioenriched α-amino amides bearing active pharmaceutical ingredients on the sidechain.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, Technical University of Denmark, Kgs. Lyngby, Denmark"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xuemeng Chen",
      "orcid": "0000-0003-3024-7488"
    },
    {
      "affs": [
        0
      ],
      "name": "Søren Kramer",
      "orcid": "0000-0001-6075-9615"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4bn67zwq606qr.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77983-2",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696686/",
  "id": "4bn67zwq606qr",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://doi.org/10.1038/s41467-026-77983-2",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1605|Asymmetric Synthesis and Catalysis"
    ]
  ],
  "openalex": "W7214177602",
  "pdf_url": "https://europepmc.org/articles/PMC13696686?pdf=render",
  "pmcid": "PMC13696686",
  "pmid": "42928082",
  "published": "2026-09-24",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/4bn67zwq606qr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:00Z",
      "native_id": "PMC13696686",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41467-026-77983-2"
    },
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42928082",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42928082"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Asymmetric Synthesis and Catalysis",
      "subfield": "organic"
    }
  ],
  "title": "Unnatural α-amino acid synthesis enabled by nickel-catalysed enantioselective hydrocarbamoylation of enamides via C‒H functionalisation",
  "title_text": "Unnatural α-amino acid synthesis enabled by nickel-catalysed enantioselective hydrocarbamoylation of enamides via C‒H functionalisation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:33:59Z",
  "url": "https://research.draconitic.com/paper/4bn67zwq606qr",
  "venue": "Nature Communications",
  "versions": []
}