{
  "abstract": "Objectives: To assess microbiological concordance, antimicrobial susceptibility testing (AST) agreement, and associated clinical characteristics of suspected urosepsis episodes using paired urine (UC) and blood cultures (BC). Methods: We retrospectively analyzed 2572 paired UC-BC episodes from 2302 adults at a tertiary-care laboratory (2018-2024). Episodes were considered concordant when UC and BC shared at least one identical pathogen. We compared pathogen spectra, culture dynamics, AST results, laboratory referral information, inflammatory markers, and survival. Multivariable logistic regression was used to identify factors associated with concordance. Results: Of 2572 episodes, 1405 (54.6%) were concordant. UC reports were finalized earlier than BC reports, with 50.4% available within 1 day. Concordant episodes showed shorter BC time-to-positivity than discordant episodes (7.8 vs 14.1 hours). Documented clinical suspicion and detection of Escherichia coli or Staphylococcus aureus in UC were associated with concordance. Among concordant Enterobacterales episodes, UC AST showed high agreement with BC AST. In exploratory analyses, concordant episodes were associated with faster decline of inflammatory markers and better survival. Conclusions: In suspected urosepsis, UC frequently identified the same pathogen as BC while providing earlier microbiological and susceptibility information. These findings support the potential early diagnostic and antimicrobial stewardship value of UC while BC results remain pending.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria",
    "Department of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Medical University of Innsbruck, Innsbruck, Austria",
    "Health Data Competence Center, Tirol Kliniken GmbH, Innsbruck, Austria",
    "Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria; Corresponding author."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Philipp Grubwieser"
    },
    {
      "affs": [
        0
      ],
      "name": "Silke Huber"
    },
    {
      "affs": [
        0
      ],
      "name": "Angelika Bauer"
    },
    {
      "affs": [
        1
      ],
      "name": "Wolfram Mayr"
    },
    {
      "affs": [
        2
      ],
      "name": "Werner O. Hackl"
    },
    {
      "affs": [
        0
      ],
      "name": "Cornelia Lass-Flörl"
    },
    {
      "affs": [
        0
      ],
      "name": "Werner Ruppitsch"
    },
    {
      "affs": [
        3
      ],
      "name": "Miriam Alisa Govrins"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4bwzcndn4mcsj.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ijid.2026.109092",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S1201971226007277",
  "id": "4bwzcndn4mcsj",
  "issns": [
    "1201-9712",
    "1878-3511"
  ],
  "landing_url": "https://doi.org/10.1016/j.ijid.2026.109092",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC109-216"
    ],
    [
      "openalex",
      "2713|Urinary Tract Infections Management"
    ]
  ],
  "openalex": "W7207627230",
  "pdf_url": "https://www.ijidonline.com/article/S1201-9712(26)00727-7/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/4bwzcndn4mcsj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:27Z",
      "native_id": "07c51bc1e26a444ca2bbb3d852713107",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.ijid.2026.109092"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Urinary Tract Infections Management",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Urine-blood culture concordance in suspected urosepsis and implications for early clinical decision-making",
  "title_text": "Urine-blood culture concordance in suspected urosepsis and implications for early clinical decision-making",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:20:20Z",
  "url": "https://research.draconitic.com/paper/4bwzcndn4mcsj",
  "venue": "International Journal of Infectious Diseases",
  "versions": []
}