{
  "abstract": "Signal Amplification By Reversible Exchange (SABRE) delivers rapid and inexpensive NMR signal enhancement using parahydrogen-derived spin order, but biomedical translation requires catalysts that simultaneously deliver high polarization efficiency together with minimal residual metal contamination. Here we introduce a class of single-chain fluorinated Ir-NHC catalysts for SABRE hyperpolarization of [1-13C]pyruvate that addresses this longstanding trade-off. Retention of carbene backbone unsaturation preserves SABRE efficiency, enabling ∼4% 13C polarization with 50% parahydrogen, comparable to the benchmark Ir-IMes catalyst and approximately threefold higher than the previously reported perfluorinated Ir-SIMesF2 system under identical conditions. Combined with redissolution SABRE, aqueous extraction, and fluorinated silica filtration, one of these catalysts, Ir-IMesF1, yields aqueous hyperpolarized solutions containing <100 ppb residual iridium. The resulting aqueous formulations, while not yet suitable for direct biomedical administration, deliver efficient SABRE hyperpolarization and ultra-low residual iridium contamination, enabling real-time monitoring of in vitro pyruvate-to-lactate conversion under partial parahydrogen enrichment.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemical Sciences, Università di Padova Via Marzolo 1 35131 Padova Italy",
    "Department MESVA (Life, Health & Environmental Sciences), Università dell'Aquila Via Vetoio SNC, Località Coppito 67100 L'Aquila Italy",
    "Centre for Hyperpolarisation in Magnetic Resonance, University of York Heslington York YO10 5NY UK"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Federico Floreani"
    },
    {
      "affs": [
        0
      ],
      "name": "Ahmed Faramawy"
    },
    {
      "affs": [
        0
      ],
      "name": "Federico De Biasi"
    },
    {
      "affs": [
        0
      ],
      "name": "Denis Badocco"
    },
    {
      "affs": [
        1
      ],
      "name": "Salvatore Mamone"
    },
    {
      "affs": [
        2
      ],
      "name": "Callum A. Gater",
      "orcid": "0000-0003-2457-0238"
    },
    {
      "affs": [
        2
      ],
      "name": "Simon B. Duckett",
      "orcid": "0000-0002-9788-6615"
    },
    {
      "affs": [
        0
      ],
      "name": "Cristina Tubaro",
      "orcid": "0000-0001-7724-735X"
    },
    {
      "affs": [
        0
      ],
      "name": "Gabriele Stevanato",
      "orcid": "0000-0003-0020-1286"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4c1f9cq2yp4re.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra07354a",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657090/?tool=EBI",
  "id": "4c1f9cq2yp4re",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13657090",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1607|Advanced NMR Techniques and Applications"
    ]
  ],
  "openalex": "W7221519895",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657090/pdf/?tool=EBI",
  "pmcid": "PMC13657090",
  "pmid": "42866629",
  "published": "2026-10-12",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/4c1f9cq2yp4re.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:25Z",
      "native_id": "PMC:PMC13657090",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13657090"
    },
    {
      "first_seen": "2026-11-01T12:23:36Z",
      "native_id": "PMC13657090",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra07354a"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1607|Advanced NMR Techniques and Applications",
      "subfield": "physical"
    }
  ],
  "title": "Single-chain fluorinated Ir-NHC catalysts for efficient SABRE pyruvate hyperpolarization with average residual iridium below 100 ppb",
  "title_text": "Single-chain fluorinated Ir-NHC catalysts for efficient SABRE pyruvate hyperpolarization with average residual iridium below 100 ppb",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:20:50Z",
  "url": "https://research.draconitic.com/paper/4c1f9cq2yp4re",
  "venue": "RSC advances",
  "versions": []
}