{
  "abstract": "High-grade gliomas (HGGs) in children and adolescents and young adults (AYA) exhibit distinct biology across the neurodevelopmental spectrum. To dissect tumor-intrinsic molecular characteristics independent of developmental variation, we perform comprehensive proteogenomic analyses of tumors from 112 HGG patients aged 0–40 years. Our multi-omics analysis identifies two AYA subgroups—adolescents (aged 15–26 years) and young adults (aged 26–40 years)—with distinct molecular profiles and survival outcomes. Tumor-normal comparisons and survival modeling highlight roles of oxidative phosphorylation and neuronal system biology in glioma progression. Causal network analysis and cell line studies provide a rationale for personalized therapies targeting candidate kinases, such as CDK8. Survival modeling, clustering, and immune-landscape analyses identify proteins, post-translational modifications, and immune signatures linked to outcomes and reveal clinically relevant differences between male and female patients.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA",
    "The Center for Data Driven Discovery in Biomedicine, Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19146, USA",
    "Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99354, USA",
    "Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA",
    "Centre for Biomedical Data Science, Duke-NUS Medical School, National University of Singapore, Singapore 169857, Singapore",
    "Division of Clinical Genomics and Therapeutics, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA",
    "Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA",
    "Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA",
    "Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA",
    "Center for Cancer and Immunology Research, Children’s National Research Institute, Washington, DC 20012, USA",
    "Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC 20010, USA",
    "Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA",
    "Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA",
    "Centre for Cancer Research, Hudson Institute of Medical Research, Department of Molecular and Translational Science, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC 3168, Australia",
    "Meyer Cancer Center, Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA",
    "Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA",
    "Department of Cell Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA",
    "Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA",
    "Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 181,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Nicole L. Tignor"
    },
    {
      "affs": [
        1
      ],
      "name": "Mateusz Koptyra"
    },
    {
      "affs": [
        0
      ],
      "name": "Shrabanti Chowdhury"
    },
    {
      "affs": [
        0
      ],
      "name": "Francesca Petralia"
    },
    {
      "affs": [
        2
      ],
      "name": "Marina A. Gritsenko"
    },
    {
      "affs": [
        0
      ],
      "name": "Weiping Ma"
    },
    {
      "affs": [
        1
      ],
      "name": "Yuankun Zhu"
    },
    {
      "affs": [
        3
      ],
      "name": "Giacomo B. Marino"
    },
    {
      "affs": [
        4
      ],
      "name": "Xiaoyu Song"
    },
    {
      "affs": [
        5
      ],
      "name": "Simona Migliozzi"
    },
    {
      "affs": [
        6
      ],
      "name": "Jeffrey R. Whiteaker"
    },
    {
      "affs": [
        0
      ],
      "name": "Dmitry Rykunov"
    },
    {
      "affs": [
        7
      ],
      "name": "Yingwei Hu"
    },
    {
      "affs": [
        8
      ],
      "name": "Noshad Hosseini"
    },
    {
      "affs": [
        9,
        10
      ],
      "name": "Jo Lynne Rokita"
    },
    {
      "affs": [
        11
      ],
      "name": "Felipe da Veiga Leprevost"
    },
    {
      "affs": [
        1
      ],
      "name": "Komal S. Rathi"
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        7
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      "name": "Lijun Chen"
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        12
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      "name": "Yi-Ting Wang"
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        12
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      "name": "Karl K. Weitz"
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        2
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      "name": "Rosalie K. Chu"
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        12
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      "name": "Ronald J. Moore"
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        0
      ],
      "name": "Azra Krek"
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    {
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        0
      ],
      "name": "Weijia Fu"
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    {
      "affs": [
        0
      ],
      "name": "Xuran Wang"
    },
    {
      "affs": [
        3
      ],
      "name": "Eden Z. Deng"
    },
    {
      "affs": [
        12
      ],
      "name": "Chia-Feng Tsai"
    },
    {
      "affs": [
        12
      ],
      "name": "Tyler Sagendorf"
    },
    {
      "affs": [
        12
      ],
      "name": "Vladislav A. Petyuk"
    },
    {
      "affs": [
        12
      ],
      "name": "Tujin Shi"
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    {
      "affs": [
        2
      ],
      "name": "Thomas L. Fillmore"
    },
    {
      "affs": [
        12
      ],
      "name": "Rui Zhao"
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    {
      "affs": [
        12
      ],
      "name": "Matthew E. Monroe"
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    {
      "affs": [
        13
      ],
      "name": "Marius V. Dannappel"
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    {
      "affs": [
        13
      ],
      "name": "Paul Daniel"
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    {
      "affs": [
        6
      ],
      "name": "Lei Zhao"
    },
    {
      "affs": [
        6
      ],
      "name": "Richard G. Ivey"
    },
    {
      "affs": [
        6
      ],
      "name": "Uliana J. Voytovich"
    },
    {
      "affs": [
        14,
        15
      ],
      "name": "Tomer M. Yaron-Barir"
    },
    {
      "affs": [
        14
      ],
      "name": "Emily M. Huntsman"
    },
    {
      "affs": [
        16
      ],
      "name": "Jared L. Johnson"
    },
    {
      "affs": [
        0
      ],
      "name": "Nakib Abedin"
    },
    {
      "affs": [
        0
      ],
      "name": "Yan-chak Li"
    },
    {
      "affs": [
        17
      ],
      "name": "Mariarita Santi"
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    {
      "affs": [
        1
      ],
      "name": "Demetri Dupal"
    },
    {
      "affs": [
        1
      ],
      "name": "Jena Lilly"
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    {
      "affs": [
        1
      ],
      "name": "Adam Kraya"
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    {
      "affs": [
        1
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      "name": "Joseph M. Dybas"
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    {
      "affs": [
        1
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      "name": "Bo Zhang"
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        17
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      "name": "Chuwei Zhong"
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    {
      "affs": [
        1
      ],
      "name": "Miguel A. Brown"
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        18
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      "name": "Saksham Phul"
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      "name": "Eric Wafula"
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    {
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        18
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      "name": "Alvin Farrel"
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    {
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        1
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      "name": "Zhuangzhuang Geng"
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    {
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        1
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      "name": "Ryan J. Corbett"
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        1
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      "name": "Ammar S. Naqvi"
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        1
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      "name": "Daniel P. Miller"
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        1
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      "name": "Jennifer Mason"
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    {
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        1
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      "name": "Tatiana S. Patton"
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  "bibtex": "https://research.draconitic.com/paper/4c3j128avwqqq.bib",
  "cited_by": 0,
  "doi": "10.1016/j.xcrm.2026.103024",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710149/",
  "id": "4c3j128avwqqq",
  "issns": [
    "2666-3791"
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  "landing_url": "https://doi.org/10.1016/j.xcrm.2026.103024",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
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      "2716|Glioma Diagnosis and Treatment"
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  "openalex": "W7213462688",
  "pdf_url": null,
  "pmcid": "PMC13710149",
  "pmid": "42753723",
  "published": "2026-09-17",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/4c3j128avwqqq.ris",
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      "first_seen": "2026-10-31T12:21:10Z",
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      "url": "https://doi.org/10.1016/j.xcrm.2026.103024"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Glioma Diagnosis and Treatment",
      "subfield": "human-genetics"
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  ],
  "title": "Proteogenomic analysis of pediatric and AYA high-grade glioma reveals age-dependent biology, female-male differences, and kinase targets",
  "title_text": "Proteogenomic analysis of pediatric and AYA high-grade glioma reveals age-dependent biology, female-male differences, and kinase targets",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:10Z",
  "url": "https://research.draconitic.com/paper/4c3j128avwqqq",
  "venue": "Cell Reports Medicine",
  "versions": []
}