{
  "abstract": "Introduction: Osteoarthritis (OA) remains a degenerative joint disorder with limited treatment options.\n\nMethods: We examined miR-302c-3p expression in human OA cartilage and primary chondrocytes, validated ADAMTS5 as a direct target, and developed a PCEC/TAmP hydrogel for intra-articular delivery in a DMM mouse model.\n\nResults: miR-302c-3p was downregulated in OA cartilage and attenuated IL-1β-induced chondrocyte catabolism by reducing ADAMTS5, MMP1, and MMP13 expression while preserving COL II. The PCEC/TAmP hydrogel enabled sustained release and improved cartilage penetration of miR-302c-3p, enhancing its therapeutic efficacy in OA mice.\n\nConclusion: miR-302c-3p-loaded PCEC/TAmP hydrogel may be a promising intra-articular strategy for targeted OA treatment.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Joint Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China",
    "Department of Joint Surgery and Sports Medicine, Zhuhai People’s Hospital, Zhuhai, Guangdong, People’s Republic of China",
    "School of Materials Science and Engineering, Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yuzhou Zhao"
    },
    {
      "affs": [
        1
      ],
      "name": "Yongheng Ye"
    },
    {
      "affs": [
        2
      ],
      "name": "Tianyu Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Zeyang Yao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yong Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Dianbo Long"
    },
    {
      "affs": [
        0
      ],
      "name": "Jianhua Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaoyi Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Peiheng He"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4cdh25g76mh5w.bib",
  "cited_by": 0,
  "doi": "10.2147/ijn.s631283",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13722576/",
  "id": "4cdh25g76mh5w",
  "issns": [
    "1176-9114",
    "1178-2013"
  ],
  "landing_url": "https://doi.org/10.2147/ijn.s631283",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2745|Osteoarthritis Treatment and Mechanisms"
    ]
  ],
  "openalex": "W7223682222",
  "pdf_url": "https://www.dovepress.com/article/download/121386",
  "pmcid": "PMC13722576",
  "pmid": "42966924",
  "published": "2026-10-26",
  "publisher": "Dove Press",
  "ris": "https://research.draconitic.com/paper/4cdh25g76mh5w.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:22Z",
      "native_id": "PMC13722576",
      "source": "pmc",
      "url": "https://doi.org/10.2147/ijn.s631283"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2745|Osteoarthritis Treatment and Mechanisms",
      "subfield": "general"
    }
  ],
  "title": "MiR-302c-3p-Encapsulated Cationic TAmP PCEC Hydrogels for Targeted ADAMTS5 Suppression and Osteoarthritis Treatment",
  "title_text": "MiR-302c-3p-Encapsulated Cationic TAmP PCEC Hydrogels for Targeted ADAMTS5 Suppression and Osteoarthritis Treatment",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:22Z",
  "url": "https://research.draconitic.com/paper/4cdh25g76mh5w",
  "venue": "International Journal of Nanomedicine",
  "versions": []
}