{
  "abstract": "In this study, we explore a new approach for the mild and selective activation of C(sp3)–F bonds in fluorinated azidoalkanes. Our approach utilizes electrophilic azide groups, which promote fluoride elimination and enable nucleophilic addition to newly formed electrophilic sites. This method achieves rapid, high‐yield transformations of (per)fluoroalkyl azides into novel sulfur‐containing azides, imines, and triazoles under mild conditions and using inexpensive reagents. The reaction proceeds without metal catalysts or external energy input and displays broad functional group tolerance, including toward thiol‐sensitive motifs. Mechanistic studies supported by spectroscopy and x‐ray crystallography, corroborated by ab initio calculations, reveal key azide intermediates and establish the denitrogenation pathway via α,α‐disubstituted species. This transformation provides a practical and scalable route for the conversion of (per)fluoroalkyl azides into nitrogen‐ and sulfur‐functionalized scaffolds, advancing C─F activation processes.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Organic Chemistry and Biochemistry Czech Academy of Sciences Prague Czechia",
    "V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry The National Academy of Sciences of Ukraine Kyiv Ukraine",
    "Department of Organic Chemistry Faculty of Sciences Charles University Prague Czechia",
    "Department of Physical Chemistry University of Chemistry and Technology Prague Czechia"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Olena Shaitanova"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "María Martínez Mallo"
    },
    {
      "affs": [
        0
      ],
      "name": "Sergii Suikov"
    },
    {
      "affs": [
        0
      ],
      "name": "Blanka Klepetářová"
    },
    {
      "affs": [
        3
      ],
      "name": "Josef Filgas"
    },
    {
      "affs": [
        3
      ],
      "name": "Petr Slavíček"
    },
    {
      "affs": [
        0
      ],
      "name": "Lucie Bednárová"
    },
    {
      "affs": [
        0
      ],
      "name": "Petr Beier",
      "orcid": "0000-0002-0888-7465"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4d3vsc6r1fj2a.bib",
  "cited_by": 0,
  "doi": "10.1002/chem.71323",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13715455/",
  "id": "4d3vsc6r1fj2a",
  "issns": [
    "0947-6539",
    "1521-3765"
  ],
  "landing_url": "https://doi.org/10.1002/chem.71323",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "3003|Fluorine in Organic Chemistry"
    ]
  ],
  "openalex": "W7167897647",
  "pdf_url": null,
  "pmcid": "PMC13715455",
  "pmid": "42427112",
  "published": "2026-07-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4d3vsc6r1fj2a.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:22:45Z",
      "native_id": "PMC13715455",
      "source": "pmc",
      "url": "https://doi.org/10.1002/chem.71323"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3003|Fluorine in Organic Chemistry",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Mild C─F Activation of Azido(per)Fluoroalkanes",
  "title_text": "Mild C─F Activation of Azido(per)Fluoroalkanes",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:45Z",
  "url": "https://research.draconitic.com/paper/4d3vsc6r1fj2a",
  "venue": "Chemistry (Weinheim an Der Bergstrasse, Germany)",
  "versions": []
}