{
  "abstract": "POTE proteins are known to be expressed in tissues such as normal prostate, placenta, ovary, testis, and embryo, and are collectively referred to as POTE-family proteins based on this organ-specific expression. The POTE gene spans 32 kb on chromosome 21q11.2, although its homologous genes are distributed across eight different chromosomes. POTEE, as a member of the POTE family, has been identified as a Cancer Germline Antigen (CGA) across several cancer types including Colorectal, Pancreatic, Breast, Liver, and Lung cancers. This study aims to elucidate the role of POTE-Paralogs (POTEE & POTEF) as CGA markers in Cervical Cancer (CaCx). Over 90% of CaCx cases are associated with persistent infection by high-risk HPV (HR-HPV); the E6 and E7 oncoproteins of HPV contribute to carcinogenesis through the degradation or inactivation of tumor suppressor proteins p53 and pRB, leading to uncontrolled cell proliferation. Consequently, HPV-positive cervical cancer cell lines HeLa and CaSki lack detectable expression of p53, and the expression of POTE-Paralogs is also markedly decreased, while the HPV-negative CaCx cell line C-33A exhibits high p53 expression correlated with marked upregulation of POTE-Paralogs. Treatment of C-33A cells with a p53-specific inhibitor reduced POTE-Paralogs expression. Conversely, restoring p53 expression in CaSki cells with the chemotherapeutic agent Doxorubicin resulted in increased expression of POTE-Paralogs. Furthermore, silencing of E6/E7 in CaSki cells led to restoration of both p53 and pRB expression, as well as an increase in POTEE & POTEF levels.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Endocrinology, CSIR- Central Drug Research Institute, Lucknow 226031, India",
    "Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Niranjan Kumar"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Rashmi Rani Sahu"
    },
    {
      "affs": [
        0
      ],
      "name": "Amrita Singh"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Akanksha Vyas"
    },
    {
      "affs": [
        0
      ],
      "name": "Saurabh Kumar"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Prerona Das"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Monika Sachdev"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4df9tg9wh6f9q.bib",
  "cited_by": 0,
  "doi": "10.5483/bmbrep.2025-0074",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13720691/",
  "id": "4df9tg9wh6f9q",
  "issns": [
    "1976-6696",
    "1976-670X"
  ],
  "landing_url": "https://doi.org/10.5483/bmbrep.2025-0074",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2713|Cervical Cancer and HPV Research"
    ]
  ],
  "openalex": "W7128408193",
  "pdf_url": "https://www.bmbreports.org/journal/download_pdf.php?doi=10.5483/BMBRep.2025-0074",
  "pmcid": "PMC13720691",
  "pmid": "41655991",
  "published": "2026-10-31",
  "publisher": "Korean Society for Biochemistry and Molecular Biology",
  "ris": "https://research.draconitic.com/paper/4df9tg9wh6f9q.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:21:31Z",
      "native_id": "PMC13720691",
      "source": "pmc",
      "url": "https://doi.org/10.5483/bmbrep.2025-0074"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Cervical Cancer and HPV Research",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Silencing of E6/E7 proteins of HPV-16 in the CaCx cell line upregulate the expression of POTE-Paralogs",
  "title_text": "Silencing of E6/E7 proteins of HPV-16 in the CaCx cell line upregulate the expression of POTE-Paralogs",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:31Z",
  "url": "https://research.draconitic.com/paper/4df9tg9wh6f9q",
  "venue": "BMB Reports",
  "versions": []
}