{
  "abstract": "Vascular dementia (VaD) is a heterogeneous cognitive disorder associated with cerebrovascular pathology and persistent vascular dysfunction. Because effective disease-modifying therapies remain limited, natural products have attracted interest as potential interventions for the complex pathology of VaD. This review examines their effects from two complementary perspectives: neuroprotection and neural repair. Experimental studies indicate that natural products can influence several interconnected processes, including redox imbalance, neuroinflammation, cell survival, blood–brain barrier dysfunction, vascular remodeling, neurogenesis, and synaptic plasticity. However, the available evidence varies considerably among isolated compounds, botanical extracts, and herbal formulations. Some isolated compounds have been supported by relatively coherent relationships between molecular targets, tissue responses, and functional outcomes, whereas evidence from clinical studies remains much more limited. We therefore consider the current mechanistic evidence together with the major challenges in pharmacokinetics, quality control, and clinical translation.",
  "abstract_shown": true,
  "affiliations": [
    "School of Pharmacy, Hunan University of Chinese Medicine",
    "Hunan Engineering Technology Research Center for Bioactive Substance Discovery of Chinese Medicine, Hunan University of Chinese Medicine",
    "Hunan Province Sino-US International Joint Research Center for Therapeutic Drugs of Senile Degenerative Diseases, Hunan University of Chinese Medicine",
    "School of Pharmacy, China Pharmaceutical University"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Qinzhe Luo"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Zhaoxing Li"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yuyuan Liao"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenshuo Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhihong Xu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Xin You"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Guannan Xue"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yan Duan"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Juan Li"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Shunxiang Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4dqr9wmezm9d5.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.1942636",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727566/?tool=EBI",
  "id": "4dqr9wmezm9d5",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1942636/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2808|Neurological Disease Mechanisms and Treatments"
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  "openalex": "W7223040836",
  "pdf_url": "https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1942636/pdf",
  "pmcid": "PMC13727566",
  "pmid": "42978823",
  "published": "2026-10-20",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/4dqr9wmezm9d5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:06Z",
      "native_id": "10.3389/fphar.2026.1942636",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1942636/full"
    },
    {
      "first_seen": "2026-11-04T15:20:46Z",
      "native_id": "PMC:PMC13727566",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13727566"
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    {
      "first_seen": "2026-11-06T12:23:25Z",
      "native_id": "PMC13727566",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fphar.2026.1942636"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2808|Neurological Disease Mechanisms and Treatments",
      "subfield": "neurology"
    }
  ],
  "title": "Treatment of vascular dementia based on neuroprotection and neural repair strategies: from pathophysiology to natural products",
  "title_text": "Treatment of vascular dementia based on neuroprotection and neural repair strategies: from pathophysiology to natural products",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:20:43Z",
  "url": "https://research.draconitic.com/paper/4dqr9wmezm9d5",
  "venue": "Frontiers in Pharmacology",
  "versions": []
}