{
  "abstract": "Background: Health Canada recommends that adults follow physical activity and dietary guidelines to reduce risk of cardiometabolic disease. However, there is a paucity of research on the effects of these guidelines on cardiometabolic health of women. This study aims to investigate the effects of a 6-month guidelines-based physical activity intervention, with or without following dietary guidelines, on biological systems involved in cardiometabolic disease development.\n\nMethods: This three-arm randomized controlled trial will recruit 180 women (60 women per arm, 30 pre-menopausal and 30 post-menopausal) with multiple risk factors for developing cardiometabolic disease: currently physically inactive, body mass index > 25 kg/m2, and ≥ 1 of central adiposity, hypertension, pre-diabetes, and dyslipidemia. Participants will be randomized with stratification by menopausal and metabolic syndrome status for 24 weeks to (1) exercise; (2) exercise + diet; or (3) stretching control. The primary outcome is change in Matsuda index (measure of insulin resistance) over 24 weeks. Secondary outcomes include Homeostatic Model Assessment for Insulin Resistance, metabolic syndrome z-score, and Framingham 10-year cardiovascular risk. Tertiary outcomes include cardiorespiratory fitness, cardiac, vascular, muscle and liver structure and function, skeletal muscle remodelling, body composition, blood biomarkers, psychosocial outcomes, and lifestyle behaviours.\n\nDiscussion: This study will reduce knowledge gaps around the effects of physical activity and diet in pre- and post-menopausal women towards a goal of evidence-based medicine to prevent cardiometabolic disease in women across the lifespan.\n\nTrial registration: This study is funded by the Canadian Institutes of Health Research, has University of Toronto research ethics approval, and is registered as a clinical trial (ClinicalTrials.gov #NCT06345937; registered on 03/28/2024, https://clinicaltrials.gov/study/NCT06345937 ).",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "name": "Jennifer S. Williams"
    },
    {
      "name": "Alfred Min"
    },
    {
      "name": "Stephanie D. Small"
    },
    {
      "name": "Alexa Govette"
    },
    {
      "name": "Barbara de Barros Gonze"
    },
    {
      "name": "Alexander Boytar"
    },
    {
      "name": "Katherine Rosati"
    },
    {
      "name": "Courtney Chang"
    },
    {
      "name": "Michelle Ha"
    },
    {
      "name": "Paula Harvey"
    },
    {
      "name": "Linda Trinh"
    },
    {
      "name": "JoAnne Arcand"
    },
    {
      "name": "Lorraine Lipscombe"
    },
    {
      "name": "Erin Howden"
    },
    {
      "name": "Robert F. Bentley"
    },
    {
      "name": "Jenna B. Gillen"
    },
    {
      "name": "Amy A. Kirkham"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4dx5st8wb26zb.bib",
  "cited_by": 0,
  "doi": "10.1186/s13063-026-10016-x",
  "fulltext_url": null,
  "id": "4dx5st8wb26zb",
  "issns": [
    "1745-6215"
  ],
  "landing_url": "https://link.springer.com/10.1186/s13063-026-10016-x",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Physical Activity and Health"
    ]
  ],
  "openalex": "W7221537930",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-12",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/4dx5st8wb26zb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:30Z",
      "native_id": "10.1186/s13063-026-10016-x",
      "source": "crossref",
      "url": "https://link.springer.com/10.1186/s13063-026-10016-x"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Physical Activity and Health",
      "subfield": "physiology"
    }
  ],
  "title": "Effects of the physical activity guidelines with or without the dietary guidelines on cardiometabolic disease risk among pre- and post-menopausal women: study protocol for the Multiple Risk Factor Intervention Trial (Ms. FIT) RCT",
  "title_text": "Effects of the physical activity guidelines with or without the dietary guidelines on cardiometabolic disease risk among pre- and post-menopausal women: study protocol for the Multiple Risk Factor Intervention Trial (Ms. FIT) RCT",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:30Z",
  "url": "https://research.draconitic.com/paper/4dx5st8wb26zb",
  "venue": "Trials",
  "versions": []
}