{
  "abstract": "Objective\n\nLocalization of epileptogenic MRI-negative focal cortical dysplasia at the bottom of the sulcus (FCDB) is challenging. This study evaluated the utility of advanced dynamic statistical parametric mapping (AdSPM), a magnetoencephalography (MEG)-based source analysis method, for detecting epileptic MRI-negative FCDB.Methods\n\nWe retrospectively analyzed MEG data using AdSPM in four patients with pathologically confirmed MRI-negative FCDB, whose seizure onset zones were identified by intracranial video-EEG (IVEEG). The most active area identified by the AdSPM was designated as the AdSPM spike source. We compared the spatial concordance of the AdSPM spike source, single moving dipole (SMD) findings, and ¹⁸F-FDG PET/MRI findings with seizure onset and resection areas. An additional MRI-negative patient without seizures during IVEEG monitoring was analyzed separately for concordance with the resection area.Results\n\nThe AdSPM spike source localized to the seizure onset zone and was included in the resection area in all four patients with an identified seizure onset zone. SMD findings were mislocalized relative to the seizure onset zone and resection area. PET/MRI was concordant with the seizure onset zone in one of three evaluable patients and with the resection area in three of four patients. In the patient without seizures during IVEEG, AdSPM and PET/MRI were concordant with the resection area; however, the SMD findings were mislocalized.Conclusions\n\nAdSPM noninvasively and neurophysiologically localizes epileptic MRI-negative FCDB and may provide useful information for presurgical evaluations.Significance\n\nThis is the first diagnostic application of AdSPM for MRI-negative FCDB.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan.",
    "Department of Clinical Engineering, Japan Healthcare University, Sapporo, Japan.",
    "Department of Diagnostic Imaging, Faculty of Medicine, Hokkaido University, Sapporo, Japan.",
    "Department of Neurology, Nakamura Memorial Hospital, Hokkaido, Japan.",
    "Department of Neurosurgery, Nakamura Memorial Hospital, Hokkaido, Japan.",
    "Department of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.",
    "Department of Neurosurgery, Sapporo Medical University, School of Medicine, Sapporo, Japan.",
    "Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 20,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yasuyoshi Hiramatsu"
    },
    {
      "affs": [
        0
      ],
      "name": "Midori Nakajima"
    },
    {
      "affs": [
        1
      ],
      "name": "Fumiya Takeuchi"
    },
    {
      "affs": [
        0
      ],
      "name": "Masashi Narugami"
    },
    {
      "affs": [
        0
      ],
      "name": "Satoshi Yamada"
    },
    {
      "affs": [
        0
      ],
      "name": "Sachiko Nakakubo"
    },
    {
      "affs": [
        0
      ],
      "name": "Takeru Goto"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuhei Kimura"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuki Ueda"
    },
    {
      "affs": [
        2
      ],
      "name": "Noriyuki Fujima"
    },
    {
      "affs": [
        2
      ],
      "name": "Kenji Hirata"
    },
    {
      "affs": [
        3
      ],
      "name": "Yuuki Ishida"
    },
    {
      "affs": [
        4
      ],
      "name": "Yoko Aburakawa"
    },
    {
      "affs": [
        5
      ],
      "name": "Keiya Iijima"
    },
    {
      "affs": [
        5
      ],
      "name": "Masaki Iwasaki"
    },
    {
      "affs": [
        6
      ],
      "name": "Rei Enatsu"
    },
    {
      "affs": [
        6
      ],
      "name": "Nobuhiro Mikuni"
    },
    {
      "affs": [
        7
      ],
      "name": "Hideaki Shiraishi"
    },
    {
      "affs": [
        0
      ],
      "name": "Atsushi Manabe"
    },
    {
      "affs": [
        0
      ],
      "name": "Kiyoshi Egawa"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4e6d0fhxx3w67.bib",
  "cited_by": 0,
  "doi": "10.1016/j.cnp.2026.09.007",
  "fulltext_url": "https://europepmc.org/articles/PMC13685996",
  "id": "4e6d0fhxx3w67",
  "issns": [
    "2467-981X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42910304",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2738|Epilepsy research and treatment"
    ]
  ],
  "openalex": "W7215038891",
  "pdf_url": "https://europepmc.org/articles/PMC13685996?pdf=render",
  "pmcid": "PMC13685996",
  "pmid": "42910304",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4e6d0fhxx3w67.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42910304",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42910304"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Epilepsy research and treatment",
      "subfield": "psychiatry"
    }
  ],
  "title": "Epileptic hub in MRI-negative focal cortical dysplasia using advanced dynamic statistical parametric mapping and magnetoencephalography.",
  "title_text": "Epileptic hub in MRI-negative focal cortical dysplasia using advanced dynamic statistical parametric mapping and magnetoencephalography.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/4e6d0fhxx3w67",
  "venue": "Clinical neurophysiology practice",
  "versions": []
}