{
  "abstract": "No validated biomarkers beyond PD-L1 currently guide immune checkpoint inhibition (ICI) in advanced triple-negative breast cancer (TNBC), and how tumors remodel their microenvironment in response to ICI remains incompletely understood. We perform a temporal analysis of patients with advanced TNBC treated with chemo-immunotherapy in the SYNERGY trial (NCT03616886; n = 84) and the EORTC-1553-SPECTA initiative (NCT02834884; n = 38) using RNA sequencing, whole-exome sequencing, multiplex immunofluorescence, and imaging mass cytometry. A transcriptomic progression-free survival (PFS)-based risk signature stratifies outcomes and is validated across ICI-treated cohorts, while showing context-dependent behavior in non-ICI settings. Favorable outcomes are associated with immune-enriched tumors with organized lymphoid architecture, while poor outcomes are linked to fibrotic, angiogenic microenvironments with frequent PI3K alterations. Upon treatment, early progression was characterized by fibrovascular remodeling, macrophage expansion, and upregulation of alternative immunosuppressive mediators. These findings establish fibrovascular and myeloid reprogramming as a coordinated resistance program, identify actionable therapeutic targets, and support microenvironment stratification in future ICI-based trials.",
  "abstract_shown": true,
  "affiliations": [
    "Breast Cancer Translational Research Laboratory J-C Heuson (BCTL), Institut Jules Bordet, Université Libre de Bruxelles (ULB), Bruxelles, Belgium",
    "Hôpital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium",
    "EORTC Headquarters, Brussels, Belgium",
    "Institut Gustave Roussy, Villejuif, France",
    "Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Warsaw, Poland",
    "Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland",
    "Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland",
    "The Healthcare Business of Merck KGaA, Darmstadt, Germany",
    "Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland",
    "Center of Experimental Therapeutics, CHUV, Lausanne, Switzerland",
    "IFOM ETS, the AIRC Institute of Molecular Oncology, Milan, Italy",
    "Medical Oncology Department, Institut Curie, Paris, France",
    "Computational and Systems Biology of Cancer, Institut Curie, INSERM U1331, Mines ParisTech, PSL University, Paris, France",
    "Computational Medicine, Servier Research & Development, Saclay, France",
    "Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy",
    "Medical Oncology Department, Instituto Valenciano de Oncologia, Valencia, Spain",
    "Grupo Español de Investigación Cáncer de Mama (GEICAM), San Sebastián de los Reyes, Spain",
    "Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium",
    "Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands",
    "Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands",
    "Centre Oscar Lambret, Lille, France",
    "Centre Hospitalier Universitaire UCL Namur (site Sainte Elisabeth), Namur, Belgium",
    "Instituto Português de Oncologia do Porto, Porto, Portugal",
    "National Cancer Center of Vilnius University Hospital Santaros clinics, Vilnius, Lithuania",
    "Faculty of Medicine, Vilnius University, Vilnius, Lithuania",
    "Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA",
    "Institute of AI for Health, Helmholtz Munich, Neuherberg, Germany"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 36,
  "authors": [
    {
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        0
      ],
      "name": "Nicolaas Van Renne"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Elisa Agostinetto"
    },
    {
      "affs": [
        0
      ],
      "name": "Andrea Joaquín García"
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    {
      "affs": [
        2,
        3
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      "name": "Marie Morfouace"
    },
    {
      "affs": [
        4
      ],
      "name": "Marcin Możejko"
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    {
      "affs": [
        0
      ],
      "name": "Zoë Denis"
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    {
      "affs": [
        5,
        6
      ],
      "name": "Sophie Déglise"
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    {
      "affs": [
        5,
        6
      ],
      "name": "Bernd Bodenmiller"
    },
    {
      "affs": [
        7
      ],
      "name": "Henoch S. Hong"
    },
    {
      "affs": [
        0
      ],
      "name": "David Venet"
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    {
      "affs": [
        0
      ],
      "name": "Marcela Carausu"
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    {
      "affs": [
        8
      ],
      "name": "Robin Liechti"
    },
    {
      "affs": [
        9
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      "name": "Stéphanie Tissot"
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    {
      "affs": [
        9
      ],
      "name": "Sylvie Rusakiewicz"
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    {
      "affs": [
        0,
        10
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      "name": "Mattia Rediti"
    },
    {
      "affs": [
        1
      ],
      "name": "Xavier Catteau"
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    {
      "affs": [
        5,
        6
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      "name": "Daniel Schulz"
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    {
      "affs": [
        11
      ],
      "name": "Delphine Loirat"
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    {
      "affs": [
        12,
        13
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      "name": "Daniel Herrero Saboya"
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    {
      "affs": [
        1
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      "name": "Philippe Aftimos"
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    {
      "affs": [
        14
      ],
      "name": "Matteo Benelli"
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    {
      "affs": [
        15,
        16
      ],
      "name": "Angel L. Guerrero-Zotano"
    },
    {
      "affs": [
        1
      ],
      "name": "Andrea Gombos"
    },
    {
      "affs": [
        17
      ],
      "name": "Hans Wildiers"
    },
    {
      "affs": [
        18
      ],
      "name": "Jip Van Dinter"
    },
    {
      "affs": [
        18,
        19
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      "name": "Ariane Sickinghe"
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    {
      "affs": [
        20
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      "name": "Nicolas Penel"
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    {
      "affs": [
        21
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      "name": "Jean-Charles Goeminne"
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    {
      "affs": [
        22
      ],
      "name": "Júlio Oliveira"
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    {
      "affs": [
        23,
        24
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      "name": "Birute Brasiuniene"
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    {
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        11
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      "name": "Emanuela Romano"
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    {
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      "name": "Justin M. Balko"
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        19
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      "name": "Marleen Kok"
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    {
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        26
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      "name": "Ewa Szczurek"
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    {
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        1
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      "name": "Christos Sotiriou"
    },
    {
      "affs": [
        0,
        1
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      "name": "Laurence Buisseret"
    }
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  "bibtex": "https://research.draconitic.com/paper/4e8swv0h1m6mk.bib",
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  "doi": "10.1016/j.xcrm.2026.103080",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710547/",
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  "language": "en",
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  "pmcid": "PMC13710547",
  "pmid": "42810342",
  "published": "2026-09-29",
  "publisher": "Elsevier",
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      "origin": "openalex:2730|Cancer Immunotherapy and Biomarkers",
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  "title": "A multi-omics analysis of advanced triple-negative breast cancer identifies predictors to chemo-immunotherapy and on-treatment dynamics",
  "title_text": "A multi-omics analysis of advanced triple-negative breast cancer identifies predictors to chemo-immunotherapy and on-treatment dynamics",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:30Z",
  "url": "https://research.draconitic.com/paper/4e8swv0h1m6mk",
  "venue": "Cell Reports Medicine",
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