{
  "abstract": "A cardinal factor in the regulation of mRNA life and function is the cap-binding protein eIF4E. eIF4E promotes the recruitment of mRNA to the ribosome during the initiation step of translation, but other activities have been described, including mRNA processing, export, and storage. To perform these functions, eIF4E must associate with the mRNA cap and a number of different eIF4E-interacting proteins (4E-IPs). Thus, eIF4E has evolved as a key interface between RNA metabolism, gene expression, and development. In Drosophila melanogaster, seven genes encode eight eIF4E cognate proteins that have functionally diverged to perform different activities. We review the structure, interactors, biochemistry, and activities of the Drosophila eIF4E paralogs, which represent a paradigm of divergence during metazoan development.",
  "abstract_shown": true,
  "affiliations": [
    "MRNA and Cancer Laboratory, Subdirección de Investigación Básica, Instituto Nacional de Cancerología (INCan; National Institute of Cancer), Mexico City, Mexico",
    "Institut für Biochemie und Molekulare Medizin (IBMM), University of Bern, Bern, Switzerland",
    "Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada",
    "Cell & Systems Biology Program, Sickkids Research Institute, Toronto, ON, Canada",
    "Department of Biology, McGill University, Montreal, QC, Canada",
    "Department of Biochemistry and Goodman Cancer Institute, McGill University, Montreal, Canada"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Greco Hernández",
      "orcid": "0000-0002-5318-4443"
    },
    {
      "affs": [
        1
      ],
      "name": "Daniela Ross-Kaschitza",
      "orcid": "0000-0003-1367-0671"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Julie A. Brill",
      "orcid": "0000-0002-5925-9901"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Brook L. Falk"
    },
    {
      "affs": [
        4
      ],
      "name": "Paul Lasko",
      "orcid": "0000-0002-4037-3501"
    },
    {
      "affs": [
        5
      ],
      "name": "Nahum Sonenberg",
      "orcid": "0000-0002-4707-8759"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4eefz8a0fjpqv.bib",
  "cited_by": 0,
  "doi": "10.1080/15476286.2026.2753988",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13733232/",
  "id": "4eefz8a0fjpqv",
  "issns": [
    "1547-6286",
    "1555-8584"
  ],
  "landing_url": "https://doi.org/10.1080/15476286.2026.2753988",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review Article"
    ],
    [
      "openalex",
      "1312|RNA and protein synthesis mechanisms"
    ]
  ],
  "openalex": "W7224407467",
  "pdf_url": "https://www.tandfonline.com/doi/pdf/10.1080/15476286.2026.2753988?needAccess=true",
  "pmcid": "PMC13733232",
  "pmid": "42952020",
  "published": "2026-10-28",
  "publisher": "Taylor & Francis",
  "ris": "https://research.draconitic.com/paper/4eefz8a0fjpqv.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:23:04Z",
      "native_id": "PMC13733232",
      "source": "pmc",
      "url": "https://doi.org/10.1080/15476286.2026.2753988"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|RNA and protein synthesis mechanisms",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Drosophila eIF4E paralogs: a paradigm of functional divergence",
  "title_text": "Drosophila eIF4E paralogs: a paradigm of functional divergence",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:23:04Z",
  "url": "https://research.draconitic.com/paper/4eefz8a0fjpqv",
  "venue": "RNA Biology",
  "versions": []
}