{
  "abstract": "Background: Moderate‐to‐severe thrombocytopenia (platelet count < 100 × 109/L) occurs in fewer than 1% of pregnancies, posing management challenges, particularly surrounding eligibility for neuraxial anesthesia. Although recent anesthesia guidelines recommend a platelet threshold ≥ 70 × 109/L, outcomes data applying these recommendations in moderate‐to‐severe thrombocytopenia remain limited.\n\nMethods: We conducted a retrospective study of 306 pregnancy encounters at a tertiary U.S. center (January 2018–December 2022) with ≥ 1 documented platelet count < 100 × 109/L. Etiology, platelet nadir, hematology consultation, treatment patterns, and neuraxial anesthesia (NA) use were assessed from antepartum through postpartum discharge.\n\nResults: Gestational thrombocytopenia (gTCP) was the most common etiology (29%, n = 92). Thrombocytopenia severity differed across etiology, with higher platelet nadirs in gTCP (mean 84, median 88.5 × 109/L) compared with ITP (mean 62, median 66 × 109/L). Overall, 15% of pregnancies received hematology consultation, the majority of which were for individuals with ITP, and 78% underwent NA. Among pregnancies complicated by ITP, 71% received NA. Hematology consultation in ITP was associated with lower platelet nadirs and higher treatment rates.\n\nConclusions: In this cohort of moderate‐to‐severe thrombocytopenia, institutional adherence to guideline‐recommended platelet thresholds was high and associated with excellent neuraxial safety outcomes. These findings provide real‐world support for current anesthesia recommendations in a higher‐risk obstetric population.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Internal Medicine University of Utah Salt Lake City Utah USA",
    "Division of Hematology and Hematological Malignancies, Huntsman Cancer Institute University of Utah Salt Lake City Utah USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mackenzie E. Lemieux",
      "orcid": "0000-0001-6015-8668"
    },
    {
      "affs": [
        1
      ],
      "name": "Ming Y. Lim",
      "orcid": "0000-0001-5208-3387"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4egjjz3ht4zyc.bib",
  "cited_by": 0,
  "doi": "10.1111/ijlh.70187",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13730001/",
  "id": "4egjjz3ht4zyc",
  "issns": [
    "1751-5521",
    "1751-553X"
  ],
  "landing_url": "https://doi.org/10.1111/ijlh.70187",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Cell Counting/Automation"
    ],
    [
      "heading",
      "ORIGINAL ARTICLE"
    ],
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2720|Platelet Disorders and Treatments"
    ]
  ],
  "openalex": "W7167025731",
  "pdf_url": null,
  "pmcid": "PMC13730001",
  "pmid": "42389841",
  "published": "2026-07-02",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4egjjz3ht4zyc.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:22:41Z",
      "native_id": "PMC13730001",
      "source": "pmc",
      "url": "https://doi.org/10.1111/ijlh.70187"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2720|Platelet Disorders and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Thrombocytopenia in Pregnancy: A 5‐Year Analysis of Characteristics and Practices From a Tertiary Academic Center",
  "title_text": "Thrombocytopenia in Pregnancy: A 5‐Year Analysis of Characteristics and Practices From a Tertiary Academic Center",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:41Z",
  "url": "https://research.draconitic.com/paper/4egjjz3ht4zyc",
  "venue": "International Journal of Laboratory Hematology",
  "versions": []
}