{
  "abstract": "Aims: Myocardial oedema is a hallmark of takotsubo syndrome (TTS). Cardiac magnetic resonance (CMR) T2 mapping quantifies myocardial oedema, but its prognostic value in TTS is unclear. We evaluated the association between CMR-derived global myocardial T2 and major adverse cardiovascular and cerebrovascular events (MACE).\n\nMethods and results: We retrospectively identified consecutive TTS patients undergoing CMR with tissue mapping within 30 days of admission. Imaging was re-analysed, blinded to clinical data. The primary endpoint was MACE (all-cause death, heart failure hospitalization, recurrent TTS, stroke, or transient ischaemic attack). Time-dependent receiver operating characteristic (ROC) analysis derived a T2 threshold. Prespecified covariates were summarized by ridge-penalized Cox into a single linear predictor for adjustment. A Firth-penalized Cox model tested robustness. Among 110 patients (median age 68 years; 91% women), median global T2 was 56 ms (IQR 53–60), and 17 (15.5%) experienced MACE over a median follow-up of 763 days (IQR 525–1357). T2 ≥ 63 ms predicted 1-year MACE (AUC 0.671, sensitivity 56%, specificity 89%) and separated Kaplan–Meier curves (log-rank P = 0.003). In ridge-penalized Cox models, each 5 ms increase in global T2 was associated with MACE (HR 1.40, 95% CI 1.06–1.87; P = 0.020). This association was also observed after adjustment in the Firth-penalized model (HR 1.70, 95% CI 1.20–2.40; P = 0.004). An internally derived threshold of T2 ≥ 63 ms was also associated with MACE but showed modest 1-year discrimination (AUC 0.671).\n\nConclusion: Global myocardial T2 may provide incremental prognostic information beyond prespecified clinical and imaging indices in TTS and refine risk stratification.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Yoshito Kadoya",
      "orcid": "0000-0001-8333-2219"
    },
    {
      "name": "Jerald Lim",
      "orcid": "0000-0001-8809-2605"
    },
    {
      "name": "Mohammed Alaqaili",
      "orcid": "0009-0002-6874-1756"
    },
    {
      "name": "Jamilah Mohammed Al-Harbi"
    },
    {
      "name": "Pape-Mamadou Sene"
    },
    {
      "name": "Mohammed El Mehdi El Yamani",
      "orcid": "0000-0003-4841-0896"
    },
    {
      "name": "Rebecca E Thornhill"
    },
    {
      "name": "Andrew M Crean",
      "orcid": "0000-0002-2038-9178"
    },
    {
      "name": "D Ian Paterson",
      "orcid": "0000-0003-4529-3102"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4ejzpcp909crf.bib",
  "cited_by": 0,
  "doi": "10.1093/ehjci/jeag243",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13721763/",
  "id": "4ejzpcp909crf",
  "issns": [
    "2047-2404",
    "2047-2412"
  ],
  "landing_url": "https://doi.org/10.1093/ehjci/jeag243",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "AcademicSubjects/MED00200"
    ],
    [
      "heading",
      "Eurheartj/31"
    ],
    [
      "heading",
      "Eurheartj/33"
    ],
    [
      "heading",
      "Eurheartj/48"
    ],
    [
      "heading",
      "Eurheartj/51"
    ],
    [
      "heading",
      "Original Paper"
    ],
    [
      "openalex",
      "2705|Takotsubo Cardiomyopathy and Associated Phenomena"
    ]
  ],
  "openalex": "W7211890501",
  "pdf_url": "https://academic.oup.com/ehjcimaging/advance-article-pdf/doi/10.1093/ehjci/jeag243/70979536/jeag243.pdf",
  "pmcid": "PMC13721763",
  "pmid": "42704079",
  "published": "2026-09-07",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/4ejzpcp909crf.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:22:24Z",
      "native_id": "PMC13721763",
      "source": "pmc",
      "url": "https://doi.org/10.1093/ehjci/jeag243"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Takotsubo Cardiomyopathy and Associated Phenomena",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Prognostic value of cardiac magnetic resonance global T2 mapping in patients with takotsubo syndrome",
  "title_text": "Prognostic value of cardiac magnetic resonance global T2 mapping in patients with takotsubo syndrome",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:24Z",
  "url": "https://research.draconitic.com/paper/4ejzpcp909crf",
  "venue": "European Heart Journal Cardiovascular Imaging",
  "versions": []
}