{
  "abstract": "3D PDAC-TME model to observe and quantify T cell infiltration across the vasculature. In a three-channel microfluidic device, PDAC cells are cultured in a collagen matrix in the central channel surrounded, on one side, by endothelial cells (ECs) to mimic a blood vessel and, on the opposite side, by pancreatic stellate cells (PSCs) to simulate exocrine pancreas. The migration of T cells toward the tumor is quantified based on their activation state and TME composition. The presence of EC-lining drastically reduces T cell infiltration, confirming the essential role of the vasculature in controlling T cell trafficking. We show that activated T cells migrate ∼50% more than the not-activated ones toward the cancer cells. Correspondingly, in the absence of cancer cells, both activated and not-activated T cells present similar migration toward the PSCs. The proposed approach could help researchers in testing and optimizing immunotherapies for pancreatic cancer.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "Hilaria Mollica"
    },
    {
      "name": "Yi Juan Teo"
    },
    {
      "name": "Alrina Shin Min Tan"
    },
    {
      "name": "Damien Zhi Ming Tan"
    },
    {
      "name": "Paolo Decuzzi"
    },
    {
      "name": "Andrea Pavesi"
    },
    {
      "name": "Giulia Adriani"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4ezb61fmx2c76.bib",
  "cited_by": 32,
  "doi": "10.1039/d1bm00210d",
  "fulltext_url": null,
  "id": "4ezb61fmx2c76",
  "issns": [
    "2047-4830"
  ],
  "landing_url": "https://hal.science/hal-05776435v1",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.imm"
    ],
    [
      "hal",
      "2.sdv.imm.ia"
    ],
    [
      "openalex",
      "2204|3D Printing in Biomedical Research"
    ]
  ],
  "openalex": "W3210582147",
  "pdf_url": "https://pubs.rsc.org/en/content/articlepdf/2021/bm/d1bm00210d",
  "pmcid": null,
  "pmid": "34706370",
  "published": "2026-10-03",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4ezb61fmx2c76.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:46Z",
      "native_id": "hal-05776435",
      "source": "hal",
      "url": "https://hal.science/hal-05776435v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.imm",
      "subfield": "immunology"
    }
  ],
  "title": "A 3D pancreatic tumor model to study T cell infiltration",
  "title_text": "A 3D pancreatic tumor model to study T cell infiltration",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:46Z",
  "url": "https://research.draconitic.com/paper/4ezb61fmx2c76",
  "venue": "Biomaterials Science",
  "versions": []
}