{
  "abstract": "SUMMARY There is an urgent need to comprehensively catalog senescence markers across cell types in an organism in order to characterize ‘senotypes’ and senescent cell heterogeneity. Here, we profiled the transcriptomes and proteomes in 14 different primary human cell types undergoing over 30 senescence paradigms to create a senescence catalog we termed ‘SenCat’. We found that, while senescent cells from all primary tissue types did not share a single unique marker, they did activate shared specific metabolic and damage-response pathways implicated in tissue repair. Machine learning analysis of the SenCat transcriptomic and proteomic datasets successfully identified independent sets of senescent human cells, and senescent-like cells in mouse lung and kidney. In sum, SenCat represents a much-needed resource to identify senescent cells across tissues in the body. HIGHLIGHTS Identifying senescent cells in organisms in vivo remains a challenge We created SenCat: a catalog transcriptomes and proteomes of senescent primary cells Machine learning (ML) analysis of SenCat identified robust senescence scores ML-derived senescence scores uncovered senescent-like cell dynamics in vivo",
  "abstract_shown": true,
  "affiliations": [
    "Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program (NIA IRP), National Institutes of Health (NIH), Baltimore, MD, USA",
    "Translational Gerontology Branch, NIA IRP, NIH, Baltimore, MD, USA",
    "Center for Alzheimer's and Related Dementias, NIA IRP and National Institute of Neurological Disorders and Stroke (NINDS) IRP, NIH, Bethesda, MD, USA",
    "Center for Alzheimer's and Related Dementias, NIA IRP and National Institute of Neurological Disorders and Stroke (NINDS) IRP, NIH, Bethesda, MD, USA; DataTecnica LLC, Washington, DC 20812, USA",
    "Translational Gerontology Branch, NIA IRP, NIH, Baltimore, MD, USA. Electronic address: nathan.basisty@nih.gov",
    "Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program (NIA IRP), National Institutes of Health (NIH), Baltimore, MD, USA. Electronic address: myriam-gorospe@nih.gov"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 29,
  "authors": [
    {
      "name": "Carlos Anerillas",
      "orcid": "0000-0003-4424-7913"
    },
    {
      "affs": [
        0
      ],
      "name": "Gisela Altés",
      "orcid": "0000-0002-6669-5410"
    },
    {
      "affs": [
        0
      ],
      "name": "Katarína Grešová",
      "orcid": "0000-0002-1136-0832"
    },
    {
      "affs": [
        0
      ],
      "name": "Dimitrios Tsitsipatis",
      "orcid": "0009-0002-6399-034X"
    },
    {
      "affs": [
        0
      ],
      "name": "Krystyna Mazan-Mamczarz",
      "orcid": "0009-0005-1545-0500"
    },
    {
      "affs": [
        1
      ],
      "name": "Reema Banarjee",
      "orcid": "0000-0003-0161-0188"
    },
    {
      "affs": [
        1
      ],
      "name": "Ana S.G. Cunningham"
    },
    {
      "affs": [
        0
      ],
      "name": "Martín Salamini-Montemurri",
      "orcid": "0000-0002-0149-5493"
    },
    {
      "affs": [
        0
      ],
      "name": "Jen‐Hao Yang",
      "orcid": "0009-0004-4320-0843"
    },
    {
      "affs": [
        0
      ],
      "name": "Rachel B. Munk",
      "orcid": "0000-0003-2300-1770"
    },
    {
      "affs": [
        0
      ],
      "name": "Martina Rossi"
    },
    {
      "affs": [
        0
      ],
      "name": "Yulan Piao"
    },
    {
      "affs": [
        1
      ],
      "name": "Bradley Olinger",
      "orcid": "0009-0007-6196-4443"
    },
    {
      "affs": [
        1
      ],
      "name": "Quinn Strassheim",
      "orcid": "0000-0003-2933-1930"
    },
    {
      "affs": [
        0
      ],
      "name": "Jennifer L. Martindale",
      "orcid": "0000-0002-3234-6861"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinshui Fan"
    },
    {
      "affs": [
        0
      ],
      "name": "Chang‐Yi Cui",
      "orcid": "0000-0002-9856-9427"
    },
    {
      "affs": [
        0
      ],
      "name": "Supriyo De",
      "orcid": "0000-0002-2075-7655"
    },
    {
      "affs": [
        1
      ],
      "name": "Delaney V. Rutherford",
      "orcid": "0009-0002-4088-9281"
    },
    {
      "affs": [
        2
      ],
      "name": "Ying Hao"
    },
    {
      "affs": [
        3
      ],
      "name": "Zhirong Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Jessica P. Roberts",
      "orcid": "0009-0001-4103-9222"
    },
    {
      "affs": [
        2
      ],
      "name": "Yue Andy Qi",
      "orcid": "0000-0003-1914-8710"
    },
    {
      "affs": [
        0
      ],
      "name": "Kotb Abdelmohsen",
      "orcid": "0000-0001-6240-5810"
    },
    {
      "affs": [
        1
      ],
      "name": "Rafael de Cabo",
      "orcid": "0000-0003-2830-5693"
    },
    {
      "affs": [
        0
      ],
      "name": "Allison B. Herman",
      "orcid": "0000-0003-3826-3247"
    },
    {
      "affs": [
        0
      ],
      "name": "Manolis Maragkakis",
      "orcid": "0000-0002-3158-1763"
    },
    {
      "affs": [
        4
      ],
      "name": "Nathan Basisty",
      "orcid": "0000-0001-6173-1139"
    },
    {
      "affs": [
        5
      ],
      "name": "Myriam Gorospe",
      "orcid": "0000-0001-5439-3434"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4f2pxyh3x4c67.bib",
  "cited_by": 12,
  "doi": "10.1016/j.molcel.2026.05.017",
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  "id": "4f2pxyh3x4c67",
  "issns": [
    "1097-2765",
    "1097-4164"
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  "landing_url": "https://doi.org/10.1016/j.molcel.2026.05.017",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1307|Telomeres, Telomerase, and Senescence"
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    [
      "openalex",
      "2737|Telomeres, Telomerase, and Senescence"
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  "openalex": "W7164317747",
  "pdf_url": null,
  "pmcid": "PMC13004134",
  "pmid": "41867812",
  "published": "2026-06-11",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/4f2pxyh3x4c67.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:56Z",
      "native_id": "W7164317747",
      "source": "openalex",
      "url": "https://doi.org/10.1016/j.molcel.2026.05.017"
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1307|Telomeres, Telomerase, and Senescence",
      "subfield": "cell-biology"
    },
    {
      "field": "medicine",
      "origin": "openalex:2737|Telomeres, Telomerase, and Senescence",
      "subfield": "physiology"
    }
  ],
  "title": "SenCat: Cataloging human cell senescence through multi-omic profiling of multiple senescent primary cell types",
  "title_text": "SenCat: Cataloging human cell senescence through multi-omic profiling of multiple senescent primary cell types",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:07Z",
  "url": "https://research.draconitic.com/paper/4f2pxyh3x4c67",
  "venue": "Molecular Cell",
  "versions": []
}