{
  "abstract": "An efficient synthesis of chiral piperidine derivatives via an enantioselective Brønsted base-catalyzed (8+3)-cycloaddition is reported. This strategy employs azaheptafulvenes, which undergo cycloaddition with donor-acceptor cyclopropanes serving as three-carbon building blocks, providing efficient access to a new class of chiral piperidine frameworks. The developed method enables the synthesis of a broad range of chiral piperidine derivatives fused to a seven-membered cycloheptatriene ring with high stereoselectivity, broad substrate scope, and excellent functional group tolerance. Furthermore, transformations of the obtained products were demonstrated, providing access to new chiral piperidine-based frameworks.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Organic Chemistry, Faculty of Chemistry",
    "Lodz University of Technology Żeromskiego",
    "Departament de Química Orgànica, Facultat de Química, Universitat de València, Av. Vicent Andrés Estellés 19, Burjassot, Spain, 46100"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Adam Cieśliński"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Anna Skrzyńska"
    },
    {
      "affs": [
        2
      ],
      "name": "Gonzalo Blay"
    },
    {
      "affs": [
        2
      ],
      "name": "Carlos Vila"
    },
    {
      "name": "Lukasz Albrecht",
      "orcid": "0000-0002-4669-7670"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4ffwv2wr6b030.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15008171/v1",
  "fulltext_url": null,
  "id": "4ffwv2wr6b030",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008171/v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Cyclopropane Reaction Mechanisms"
    ]
  ],
  "openalex": "W7204899714",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/4ffwv2wr6b030.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:17Z",
      "native_id": "10.26434/chemrxiv.15008171",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008171/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Cyclopropane Reaction Mechanisms",
      "subfield": "organic"
    }
  ],
  "title": "Construction of Chiral Piperidine Scaffold through an Enantioselective (8+3)-Cycloaddition of Donor-Acceptor Cyclopropanes with Azaheptafulvenes",
  "title_text": "Construction of Chiral Piperidine Scaffold through an Enantioselective (8+3)-Cycloaddition of Donor-Acceptor Cyclopropanes with Azaheptafulvenes",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:17Z",
  "url": "https://research.draconitic.com/paper/4ffwv2wr6b030",
  "venue": "ChemRxiv",
  "versions": []
}