{
  "abstract": "INTRODUCTION: Lifestyle and environmental factors contributing to cardiovascular risk are components of the exposome, yet molecular signatures associated with cumulative cardiovascular risk in Alzheimer's disease (AD) remain incompletely understood.\n\nMETHODS: We analyzed blood‐based transcriptomics data from two independent cohorts: Seoul National University Bundang Hospital (SNUBH; N = 148, Korean) and Alzheimer's Disease Neuroimaging Initiative (ADNI; N = 743, predominantly European ancestry). Framingham cardiovascular risk score (FRS)–associated co‐expression network modules were identified, followed by pathway‐based enrichment, hub gene–based participant stratification, and bidirectional cross‐cohort discovery–replication analyses.\n\nRESULTS: Two co‐expression modules were associated with FRS in SNUBH, and six in ADNI. Bidirectional analyses identified two preserved modules with consistent module–FRS associations across cohorts, enriched in pathways implicated in cellular responses to exposure, including RNA–protein homeostasis, mitochondrial function, and hematopoietic processes. Hub genes in the two modules stratified participants into molecularly distinct subgroups concordant with clinical FRS categories.\n\nDISCUSSION: FRS‐associated molecular pathways were identified and warrant further investigation as potential targets for risk modification.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine Seoul Republic of Korea",
    "Department of Neurology Seoul Metropolitan Government–Seoul National University Boramae Medical Center Seoul National University College of Medicine Seoul Republic of Korea",
    "Department of Neurology Seoul National University Bundang Hospital and Seoul National University College of Medicine Seongnam Republic of Korea",
    "Department of Laboratory Medicine Seoul National University Bundang Hospital and Seoul National University College of Medicine Seongnam Republic of Korea",
    "Center for Neuroimaging Department of Radiology and Imaging Sciences Indiana Alzheimer's Disease Research Center Indiana University School of Medicine Indianapolis Indiana USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Sang‐Won Han",
      "orcid": "0000-0002-8299-9481"
    },
    {
      "affs": [
        2
      ],
      "name": "Young Ho Park"
    },
    {
      "affs": [
        2
      ],
      "name": "Jung‐Min Pyun"
    },
    {
      "affs": [
        2
      ],
      "name": "Jiyun Hwang"
    },
    {
      "affs": [
        3
      ],
      "name": "Jeong Su Park"
    },
    {
      "affs": [
        2
      ],
      "name": "SangYun Kim"
    },
    {
      "affs": [
        4
      ],
      "name": "Kwangsik Nho",
      "orcid": "0000-0002-7624-3872"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4fk7m9d7j5k1w.bib",
  "cited_by": 0,
  "doi": "10.1002/alz.71930",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696752/",
  "id": "4fk7m9d7j5k1w",
  "issns": [
    "1552-5260",
    "1552-5279"
  ],
  "landing_url": "https://doi.org/10.1002/alz.71930",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7223558303",
  "pdf_url": "https://europepmc.org/articles/PMC13696752?pdf=render",
  "pmcid": "PMC13696752",
  "pmid": "42928439",
  "published": "2026-10-01",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/4fk7m9d7j5k1w.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:03Z",
      "native_id": "PMC13696752",
      "source": "pmc",
      "url": "https://doi.org/10.1002/alz.71930"
    },
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42928439",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42928439"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "Blood transcriptomic signatures of vascular risk in Alzheimer's disease",
  "title_text": "Blood transcriptomic signatures of vascular risk in Alzheimer's disease",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:34:02Z",
  "url": "https://research.draconitic.com/paper/4fk7m9d7j5k1w",
  "venue": "Alzheimer's & Dementia",
  "versions": []
}