{
  "abstract": "ObjectivesTo assess microfilaraemia, chronic lymphatic filariasis (LF)-related morbidity, and community knowledge and self-reported preventive behaviours in a rural community in northern Ghana following prolonged mass drug administration (MDA).\n\nDesignCommunity-based cross-sectional study.\n\nSettingBirifor community, Lawra Municipality, Upper West Region, northern Ghana, from October 2024 to January 2025.\n\nParticipantsA total of 261 community members aged 10 years and above were selected using random sampling and participated in the study.\n\nOutcome measuresOutcome measures included microfilaraemia detected by night blood microscopy, chronic LF-related morbidity identified through clinical examination, and community knowledge and self-reported preventive behaviours assessed using a structured questionnaire.\n\nResultsNo microfilariae were detected (0/261; 0%). Chronic lymphoedema was identified in five individuals (1.9%), all aged over 40 years. Awareness of LF was high (95.8%), yet only 39.5% of participants demonstrated good community knowledge and self-reported preventive behaviours. Misconceptions regarding transmission, particularly beliefs that LF is hereditary or caused by spiritual factors, were common. MDA participation was high (93.1%). All five individuals with chronic lymphoedema reported loss of income, and three (60%) reported additional household income loss due to caregiving responsibilities.\n\nConclusionsNo microfilaraemia was detected, suggesting very low transmission in the study area, although residual infection cannot be excluded. Chronic LF-related morbidity and gaps in community knowledge persist despite high MDA participation. Sustained surveillance using more sensitive diagnostic approaches, together with morbidity management and disability prevention, community education and support for affected households, will be important to sustain LF elimination efforts.\n\nArticle SummaryThis community-based cross-sectional study assessed microfilaraemia, chronic lymphatic filariasis-related morbidity, and community knowledge and self-reported preventive behaviours in a rural community in northern Ghana following prolonged mass drug administration. No microfilariae were detected, suggesting very low transmission, although residual infection could not be excluded. Chronic lymphoedema persisted among a small number of older community members, and important misconceptions regarding disease transmission and prevention remained common despite high awareness and MDA participation. These findings highlight the need for continued surveillance, strengthened morbidity management and disability prevention services, and targeted community education to sustain lymphatic filariasis elimination efforts.\n\nStrengths and limitations of this studyO_LIThis study combined parasitological assessment, clinical evaluation of chronic lymphatic filariasis-related morbidity, and assessment of community knowledge and self-reported preventive behaviours within a single community-based survey. C_LIO_LIThe study was conducted in a post-mass drug administration setting, providing evidence relevant to lymphatic filariasis elimination and post-elimination surveillance programmes. C_LIO_LIUse of a participant flow diagram and complete-data analysis improved transparency and reporting of participant recruitment and inclusion. C_LIO_LIThe sample size was below the calculated minimum required for prevalence estimation, limiting the precision of prevalence estimates and the statistical power for multivariable analyses. C_LIO_LIParasitological assessment relied on night blood microscopy because circulating filarial antigen detection and molecular diagnostic methods were not available during fieldwork, limiting detection of low-level residual infection. C_LI",
  "abstract_shown": true,
  "affiliations": [
    "WHO Country Office, Accra, Ghana"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 23,
  "authors": [
    {
      "name": "C. N. Ngmembong"
    },
    {
      "name": "M. Captain-Esoah"
    },
    {
      "affs": [
        0
      ],
      "name": "S. Lareef"
    },
    {
      "name": "E. D. Angyiereyiri"
    },
    {
      "name": "M. N. Donkor"
    },
    {
      "name": "S. D. Dassah"
    },
    {
      "name": "M. K. Azameti"
    },
    {
      "name": "G. A. Motey"
    },
    {
      "name": "L. A. Adetunde"
    },
    {
      "name": "T. A. Abalori"
    },
    {
      "name": "K. K. Frempong"
    },
    {
      "name": "C. Kubio"
    },
    {
      "name": "V. Asoala"
    },
    {
      "name": "D. A. Boakye"
    },
    {
      "name": "S. K. Dadzie"
    },
    {
      "name": "F. O. Antwi"
    },
    {
      "name": "M. R. Adjei"
    },
    {
      "name": "M. P. Grobusch"
    },
    {
      "name": "D. Bakajika"
    },
    {
      "name": "F. J. Lule"
    },
    {
      "name": "E. Juma"
    },
    {
      "name": "F. Braka"
    },
    {
      "name": "D. Achu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4fksm15a95fvw.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.07.26364534",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.10.07.26364534v1.full",
  "id": "4fksm15a95fvw",
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  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.10.07.26364534v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "infectious diseases"
    ],
    [
      "openalex",
      "2725|Parasitic Diseases Research and Treatment"
    ]
  ],
  "openalex": "W7221126574",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.10.07.26364534v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4fksm15a95fvw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:34Z",
      "native_id": "10.64898/2026.10.07.26364534",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.10.07.26364534v1"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:infectious diseases",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Community knowledge, chronic morbidity and microfilaraemia following mass drug administration for lymphatic filariasis in northern Ghana: a cross-sectional study",
  "title_text": "Community knowledge, chronic morbidity and microfilaraemia following mass drug administration for lymphatic filariasis in northern Ghana: a cross-sectional study",
  "type": "preprint",
  "updated_at": "2026-10-30T12:20:34Z",
  "url": "https://research.draconitic.com/paper/4fksm15a95fvw",
  "venue": "medRxiv",
  "versions": []
}